ArticleClinical Medicine Insights. Cardiology2021
Predictors of In-hospital Mortality in Cardiogenic Shock Patients on Vasoactive or Inotropic Support.
Article in Clinical Medicine Insights. Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Efficacy and safety of dobutamine versus milrinone in cardiogenic shock: Systematic review and meta-analysis.Global cardiology science & practice · 2026Article
- Peripheral line for vasopressor administration: Prospective multicenter observational cohort study for survival and safety.PloS one · 2025Observational
- Review
- Efficacy of Milrinone and Dobutamine in Cardiogenic Shock: An Updated Systematic Review and Meta-Analysis.Critical care explorations · 2023Review
- The Usage of Concomitant Beta-Blockers with Vasopressors and Inotropes in Cardiogenic Shock.Medical sciences (Basel, Switzerland) · 2022Article
- Advances in the Staging and Phenotyping of Cardiogenic Shock: Part 1 of 2.JACC. Advances · 2022Review
- Inotropic support in cardiogenic shock: who leads the battle, milrinone or dobutamine?Annals of medicine and surgery (2012) · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThough controversial, the short-duration in-patient use of inotropes in cardiogenic shock (CS) remain an ACC/AHA Class IIa indication, and are frequently used in the initial treatment of CS. We evaluated in-patient mortality and effect on mortality risk of commonly used vasoactive inotropic medications for the medical management of SCAI stage B and C cardiogenic shock patients in a tertiary care cardiac care unit: dobutamine, dopamine, milrinone, and norepinephrine.
methodsWe retrospectively evaluated 342 patients who received dobutamine, milrinone, dopamine, norepinephrine or a combination of these medications for SCAI stage B and C cardiogenic shock. Cox proportional hazards were used to form longitudinal mortality predictions.
resultsOverall in-patient mortality was 18%. Each 1 µg/kg/minute increase in dobutamine independently corresponded to a 15% increase in risk of mortality. High dose dobutamine >3 µg/kg/minute is associated with 3-fold increased risk compared to ⩽3 µg/kg/minute (
conclusionWe demonstrate that the overall in-hospital mortality of SCAI stage B and C cardiogenic shock patients medically managed on inotropes was not in excess of prior studies. Dobutamine was independently associated with mortality, while other vasoactive inotropic medications were not. Inotropes remain a feasible method of managing SCAI stage B and C cardiogenic shock.
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