Preventive Administration of the Heat Shock Protein Hsp70 Relieves Endotoxemia-Induced Febrile Reaction in Pigeons (

K V Lapshina, I V Guzhova, I V Ekimova

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Article in Journal of evolutionary biochemistry and physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

K V LapshinaSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

I V GuzhovaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

I V EkimovaSechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

Institute of Evolutionary Physiology and Biochemistry · RUInstitute of Cytology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stress-inducible 70 kDa heat shock protein (Hsp70) can exert a protective effect on endotoxemia and sepsis due to its ability to interact with immune cells and modulate the immune response. However, it remains unknown whether Hsp70 is able to relieve endotoxemia-induced fever. We carried out a comparative study of the effects of preventive administration of the human recombinant Hsp70 (HSPA1A) on lipopolysaccharide (LPS)-induced endotoxemia in pigeons and rats with preimplanted electrodes and thermistors for recording the thermoregulation parameters (brain temperature, peripheral vasomotor reaction, muscular contractile activity). Additionally, we analyzed the dynamics of the white blood cell (WBC) count in rats under the same conditions. It was found that preventive administration of Hsp70 relieves the LPS-induced febrile reaction in pigeons and rats and accelerates the restoration of the WBC count in rats. The data obtained suggest that these warm-blooded animals share a common physiological mechanism that underlies the protective effect of Hsp70.

Indexed as

brain temperatureendotoxemiaheat shock protein 70 kDapigeonratwhite blood cells

Identifiers

PMID34720177

DOI10.1134/S0022093021050082

PMCPMC8547305

OpenAlexW3211028532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.