Evidence map›Paper›PMID 34720043›Full record

ArticleBioengineered2021

VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway.

Wen Jiang, Jun Zhang, Xudong Zhang, Chenghong Fan, Jinlong Huang

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wen JiangFirst Clinical School Medicine, Nanjing University of Chinese Medicine, Nanjing City, China.
Jun ZhangDepartment of Plastic Surgery, Affiliated Hospital Nanjing University of Chinese Medicine, Nanjing City, China.
Xudong ZhangDepartment of Aesthetic and Plastic Surgery, 903RD Hospital of Pla, Hangzhou City, China.
Chenghong FanAesthetic Surgery Department, Lishui Fan Chenghong Medical Aesthetic Clinic, Lishui City, China.
Jinlong HuangDepartment of Plastic Surgery, Affiliated Hospital Nanjing University of Chinese Medicine, Nanjing City, China.ORCID 0000-0003-3504-7477
Nanjing University of Chinese Medicine · CN81th Hospital of PLA · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic skin ulcers are a primary global health problem. Velvet antler polypeptide (VAP) regulates endothelial cell migration and angiogenic sprout. Adipose-derived stem cells (ADSCs) are reported to make pivotal impacts upon wound healing. This study aimed to explore the role of VAP combined with ADSCs in wound healing of chronic skin ulcers. The effect of VAP on phenotypes of ADSCs, and VAP (PLGA microspheres) combining with ADSCs on wound healing of chronic skin ulcers

Indexed as

MicrospheresSignal TransductionWound HealingAdipose TissueAnimalsAntlersCell MovementCell ProliferationCell ShapeChromonesChronic DiseaseHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMorpholinesNeovascularization, Physiologic2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneChromonesHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMorpholinesPeptidesperifosinePhosphatidylinositol 3-KinasesPhosphorylcholinePolylactic Acid-Polyglycolic Acid CopolymerProto-Oncogene Proteins c-aktAdipose-derived stem cells (ADSCs)chronic skin ulcersPI3K/Akt/Hif-1α pathwayVAP-PLGA microspheres (VAP-PLGA)wound healing

Identifiers

PMID34720043
PMCPMC8810082
OpenAlexW3209832573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.