ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021
Living Bacterial Hydrogels for Accelerated Infected Wound Healing.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it, 287 citations in OpenAlex.
- Recent Implementations of Hydrogel-Based Microbial Electrochemical Technologies (METs) in Sensing Applications.Sensors (Basel, Switzerland) · 2023Pooled it
- The Potential of Self-Maintainable Living Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Soft, Reactive, and Alive: A Dynamic Framework for Degradation and Functional Stability of Polymeric Biomaterials.Polymers · 2026Review
- PEG-Based Living Hydrogels Engineered for Tunable Production of Bioactive Lipopeptides.ACS applied polymer materials · 2026Article
- SCAP-Exo-Integrated CA/HACC Hydrogel Promotes Diabetic Wound Repair via miR-122-Driven Macrophage Phenotypic Transition.Advanced healthcare materials · 2026Article
- Effect of Probiotic Limosilactobacillus reuteri and Hyaluronic Acid Gel Combination Therapy on Neutrophil Response, Neovascularization, and Reepithelialization in the Wound-Healing Process Following Tooth Extraction: An In Vivo Study.European journal of dentistry · 2026Article
- A pH-responsive double network hydrogel for control of tomato bacterial wilt.Nature communications · 2026Article
- NIR-II-triggered copper single-atom catalyst depots coupling catalysis and drug release for infected chronic wounds with dysregulated inflammation.Materials today. Bio · 2026Article
- The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026Review
- Living Hydrogels: Harnessing Microorganism-Material Synergy for Next-Generation Therapeutics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Hydrogel platforms for engineered live biotherapeutics: materials, microbial integration and clinical potential.RSC pharmaceutics · 2026Review
- Probiotic and Postbiotic Delivery Systems for the Management of Chronic Wounds: A Review of Emerging Strategies.Cureus · 2026Review
- Evaluating Cytocompatibility of Corynebacterium glutamicum-poly Vinyl Alcohol Living Biomaterials for Ocular Use.Advanced healthcare materials · 2026Article
- Photoelectrocatalytic-microbial biohybrid for succinic acid synthesis.Nature communications · 2026Article
- Functionalized hydrogel sequentially deliver tannic acid and bioactive probiotics for radiation-induced skin injury.Materials today. Bio · 2026Article
- Multifunctional carboxymethyl cellulose-based hydrogels with zwitterionic and silver nanowire components for wound management.iScience · 2026Article
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- Nanozymes-Armed ProbioticResearch (Washington, D.C.) · 2026Article
- Antibacterial hydrogels for skin infected wounds: frontier approaches as antibiotic alternatives therapy.Frontiers in cellular and infection microbiology · 2026Review
- Encapsulated probiotics as antimicrobial agents: mechanisms and delivery strategies against multidrug-resistant pathogens.Frontiers in cellular and infection microbiology · 2026Review
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds and even serious tissue damage. Traditional treatments can not only kill pathogenic bacteria, but also suppress the growth of beneficial bacteria, thus destroying the balance of the damaged skin microbial ecosystem. Here, a living bacterial hydrogel scaffold is reported that accelerates infected wound healing through beneficial bacteria secreting antibacterial substances. Lactobacillus reuteri, a common probiotic, is encapsulated in hydrogel microspheres by emulsion polymerization and further immobilized in a hydrogel network by covalent cross-linking of methacrylate-modified hyaluronic acid. Owing to light-initiated crosslinking, the hydrogel dressing can be generated in situ at the wound site. This hydrogel scaffold not only protects bacteria from immune system attack, but also prevents bacteria from escaping into the local environment, thus avoiding potential threats. Both in vitro and in vivo experiments show that it has excellent ability against harmful bacteria and anti-inflammatory capabilities, promoting infected wound closure and new tissue regeneration. This work may open up new avenues for the application of living bacteria in the clinical management of infected wounds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.