ReviewInternational journal of bipolar disorders2021
Affective lability as a prospective predictor of subsequent bipolar disorder diagnosis: a systematic review.
Review in International journal of bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Development and predictors of bipolar disorder in children and adolescents with depressive disorders: a systematic review, meta-analysis, and meta-regression.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- The dynamic influence of exercise on emotional state among people with a history of mood disorder.Psychiatry research · 2026Article
- Reduced prefrontal total choline MRS levels characterize the neurodevelopmental phenotype of bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neural correlates of social affect and social cognition as risk markers of bipolar disorder.The British journal of psychiatry : the journal of mental science · 2026Article
- Psychometric properties of an Arabic translation of the short form of the affective lability scale in a sample of Lebanese adults.Frontiers in psychology · 2026Article
- Comparing Youth With Bipolar Disorder to Non-Bipolar Youth Referred for Bipolar Disorder.JAACAP open · 2025Article
- Editorial: The role of affect regulation in bipolar disorders.Frontiers in psychiatry · 2025Article
- Affective Instability: Impact of Fluctuating Emotions on Regulation and Psychological Well-Being.Behavioral sciences (Basel, Switzerland) · 2024Article
- High emotional reactivity is associated with activation of a molecularly distinct hippocampal-amygdala circuit modulated by the glucocorticoid receptor.Neurobiology of stress · 2023Article
- Specificity of affective dynamics of bipolar and major depressive disorder.Brain and behavior · 2023Article
- Moment-to-moment affective dynamics in schizophrenia and bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Differential characteristics of bipolar I and II disorders: a retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment.International journal of bipolar disorders · 2023Article
- Psychometric property study of the Affective Lability Scale-short form in Chinese patients with mood disorders.Frontiers in psychiatry · 2023Article
- Childhood trauma in bipolar disorder: new targets for future interventions.BJPsych open · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe early pathogenesis and precursors of Bipolar Disorder (BD) are poorly understood. There is some cross-sectional and retrospective evidence of affective lability as a predictor of BD, but this is subject to recall biases. The present review synthesises the prospective evidence examining affective lability and the subsequent development of BD at follow-up.
methodsThe authors performed a systematic search of PubMed, PsycInfo and Embase (1960-June 2020) and conducted hand searches to identify studies assessing affective lability (according to a conceptually-inclusive definition) at baseline assessment in individuals without a BD diagnosis, and a longitudinal follow-up assessment of bipolar (spectrum) disorders. Results are reported according to the PRISMA guidelines, and the synthesis without meta-analysis (SWiM) reporting guidelines were used to strengthen the narrative synthesis. The Newcastle-Ottawa Scale was used to assess risk of bias (ROB).
results11 articles describing 10 studies were included. Being identified as having affective lability at baseline was associated with an increased rate of bipolar diagnoses at follow-up; this association was statistically significant in six of eight studies assessing BD type I/II at follow-up and in all four studies assessing for bipolar spectrum disorder (BSD) criteria. Most studies received a 'fair' or 'poor' ROB grade.
conclusionsDespite a paucity of studies, an overall association between prospectively-identified affective lability and a later diagnosis of BD or BSD is apparent with relative consistency between studies. This association and further longitudinal studies could inform future clinical screening of those who may be at risk of BD, with the potential to improve diagnostic accuracy and facilitate early intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.