Evidence map›Paper›PMID 34719747›Full record

ArticleBiological trace element research2022

Effect of a Novel Hybrid Nanocomposite of Cisplatin-Chitosan on Induced Tissue Injury as a Suggested Drug by Reducing Cisplatin Side Effects.

Nagi M El-Shafai, Foad Farrag, Mustafa Shukry, Hany Mehany, Mohamed Aboelmaati, Ola Abu-Ali, Dalia Saleh, Mohamed Ramadan, Ibrahim El-Mehasseb

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Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nagi M El-ShafaiNanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafr El-Shaikh, 33516, Egypt. nagimohamed2016@gmail.com.
Foad FarragDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt.
Mustafa ShukryDepartment of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Shaikh, Egypt.
Hany MehanyNanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafr El-Shaikh, 33516, Egypt.
Mohamed AboelmaatiInstitute of Nanoscience and Nanotechnology, KafrelSheikh University, Kafr El-Shaikh, Egypt.
Ola Abu-AliDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Dalia SalehDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Mohamed RamadanChemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Ibrahim El-MehassebNanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, Kafr El-Shaikh, 33516, Egypt.
Kafrelsheikh University · EGTaif University · SAAlexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The self-assembly of cisplatin (Cis-Pt) and chitosan nanoparticles (Cs NPs) has been synthesized and characterized successfully by different analyses and techniques, such as scanning electron microscopy, ultraviolet-visible spectrophotometry, and Fourier transform infrared spectroscopy. The efficiency of loading Cis-Pt on Cs NPs for decreasing the side effects of Cis-Pt by loading it on Cs NP surface was revealed through histopathological and physiological measurements for the liver, testis, and kidney cells. Self-assembly hybrid nanocomposite (Cis-Pt@Cs) could improve spermatogenic cells, seminiferous tubules, and Leydig cells in the interstitial tissue. Kidney examination showed intact glomeruli with a mild increase in capsular space in addition to the intact renal tubular epithelial lining, and liver findings showed improvement in dilation and congestion of the central vein besides mild dilation of blood sinusoids in addition to a mild degree of hepatocyte vacuolation. The serum levels of hepatic, renal, and testicular marker analysis were measured, where Cis-Pt increased the serum levels of alanine aminotransferase, aspartate aminotransferase activity, urea, creatinine, and decreased testosterone levels, while synthesized self-assembly appeared normalized levels. From the results, the self-assembly hybrid nanocomposite decreases and improves the side effects of Cis-Pt.

Indexed as

ChitosanNanocompositesNanoparticlesCisplatinHumansMaleMicroscopy, Electron, ScanningSpectroscopy, Fourier Transform InfraredChitosanCisplatinAnticancer drugChitosan nanoparticleCisplatinHybrid nanocompositeSelf-assembly

Identifiers

PMID34719747
OpenAlexW3208885389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.