Evidence map›Paper›PMID 34719737›Full record

ArticleCellular and molecular life sciences : CMLS2021

Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation.

Imtiaz Iftakhar-E-Khuda, Alberto Pessia, Shuyu Zheng, Matti Kankainen, Mika Kontro, Marika Karikoski, Juha Laurila, Heidi Gerke, Sina Tadayon, Maija Hollmén and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Imtiaz Iftakhar-E-KhudaMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Alberto PessiaResearch Program in Systems Oncology (ONCOSYS), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Shuyu ZhengResearch Program in Systems Oncology (ONCOSYS), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Matti KankainenResearch Program in Systems Oncology (ONCOSYS), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Mika KontroDepartment of Hematology, Helsinki University Hospital, Helsinki, Finland.
Marika KarikoskiMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Juha LaurilaMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Heidi GerkeMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Sina TadayonMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Maija HollménMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Jing TangResearch Program in Systems Oncology (ONCOSYS), Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Beat A ImhofMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Marko SalmiMedicity Research Laboratory, University of Turku, 20520, Turku, Finland.
Sirpa JalkanenMedicity Research Laboratory, University of Turku, 20520, Turku, Finland. sirjal@utu.fi.ORCID http://orcid.org/0000-0002-1922-9732
University of Turku · FIUniversity of Helsinki · FIHelsinki University Hospital · FIUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the development of hematopoietic stem cells (HSC) has been studied in great detail, their heterogeneity and relationships to different cell lineages remain incompletely understood. Moreover, the role of Vascular Adhesion Protein-1 in bone marrow hematopoiesis has remained unknown. Here we show that VAP-1, an adhesin and a primary amine oxidase producing hydrogen peroxide, is expressed on a subset of human HSC and bone marrow vasculature forming a hematogenic niche. Bulk and single-cell RNAseq analyses reveal that VAP-1

Indexed as

Cell DifferentiationCell LineageCell ProliferationHematopoiesisAnimalsBone Marrow TransplantationCell MovementFemaleFetal BloodHematopoietic Stem CellsHumansMaleMiceMice, Inbred C57BLMice, Inbred NODMice, KnockoutVascular Cell Adhesion Molecule-1Amine oxidaseHematopoiesisOxygen radicalsStem cellsTransplantation

Identifiers

PMID34719737
PMCPMC8629906
OpenAlexW3208709527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.