ArticleJournal of Alzheimer's disease : JAD2021
Social Connectivity is Related to Mild Cognitive Impairment and Dementia.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- User experience with two computerized cognitive intervention programs for people with mild cognitive impairment.BMC geriatrics · 2025Trial
- Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Detecting cognitive impairment and psychological well-being among older adults.Machine learning. Health · 2026Article
- Radiologist burnout: AI's true black box.European radiology · 2026Review
- Association of family and friend relationship satisfaction with incident dementia: A prospective cohort study of 104,093 participants.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Editorial: Understanding the link between environmental pollutants, brain & behavior.Frontiers in psychiatry · 2026Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Connections for Ageing Well: A community healthy ageing program to promote social connection.Australasian journal on ageing · 2025Article
- The role of per- and polyfluoroalkyl substances in cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Psychological repercussions of PM air pollution in human aging: a comprehensive review of urban and rural environments.Frontiers in pharmacology · 2025Review
- Assessing the perceived influence of religion on brain health among adults in the United Arab Emirates-the Global Brain Health Survey: a cross-sectional study.Frontiers in psychology · 2025Article
- Racial Differences in the Association Between Loneliness and Cognitive Impairment Among Older Black and White Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Racial and ethnic disparities in social isolation and 11-year dementia risk among older adults in the United States.Epidemiology and psychiatric sciences · 2024Article
- Essential New Complexity-Based Themes for Patient-Centered Diagnosis and Treatment of Dementia and Predementia in Older People: Multimorbidity and Multilevel Phenomenology.Journal of clinical medicine · 2024Review
- Practical Strategies to Retain Radiologists.Journal of the American College of Radiology : JACR · 2024Article
- Cognitive function and ability to complete a web-based geriatric assessment among older adults with cancer.Journal of the American Geriatrics Society · 2024Article
- Article
- Digital oral health biomarkers for early detection of cognitive decline.BMC public health · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundEvidence supports a relationship between loneliness, social isolation, and dementia, but less is known about whether social connections confer protection against cognitive decline in disadvantaged neighborhoods.
objectiveThis longitudinal population-based study examines the relationship between social connectivity and cognitive impairment in a multi-ethnic cohort with low socioeconomic status and high vascular disease risk.
methodsNorthern Manhattan Study participants self-reported frequency of social visits, phone calls, satisfaction with social visits, number of friends, and loneliness at baseline, and were followed prospectively with a series of neuropsychological assessments. Social connectivity was examined in relation to incident mild cognitive impairment (MCI)/dementia using logistic regression adjusting for demographics and vascular risk factors.
resultsAmong 952 participants (mean age at first neuropsychological assessment = 69±8 years, 62% women, 17% Black, 13% white, 68% Hispanic), 24% developed MCI/dementia. Participants who had phone contact with friends/family 2 + times/week (91%) had a lower odds of MCI/dementia (OR = 0.52, 95% CI = 0.31-0.89), with no association for frequency of in-person visits. Compared to those who were neither socially isolated (≥3 friends) nor lonely (reference, 73%), those who were socially isolated and lonely (3%) had an increased odds of MCI/dementia (OR = 2.89, 95% CI = 1.19-7.02), but differences were not observed for those who were socially isolated but not lonely (10%, OR = 1.05, 95% CI = 0.60-1.84), nor those who were lonely but not isolated (11%, OR = 1.58, 95% CI = 0.97-2.59).
conclusionThis study raises the possibility that social connections confer some protection for cognitive health in the face of adversity and supports potential opportunities for community social interventions for improving cognition in disadvantaged populations.
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Registered trials
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