ArticleThe International journal of risk & safety in medicine2022
Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin.
Article in The International journal of risk & safety in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pharmacological treatment of antidepressant-induced sexual dysfunction in women: A systematic review and meta-analysis of randomized clinical trials.Clinics (Sao Paulo, Brazil) · 2025Pooled it
- The impact of cell-based therapy on female sexual dysfunction: a systematic review and meta-analysis.Sexual medicine reviews · 2023Pooled it
- "It's taken away the most fundamental things about being human": the lived experience and impact of post-SSRI sexual dysfunction.International journal of qualitative studies on health and well-being · 2026Article
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- Article
- Sexual dysfunction associated with antidepressants and antipsychotics: a structured narrative review of mechanisms, assessment, and personalized management.Frontiers in psychiatry · 2026Review
- Applications of pelvic neurophysiology testing in clinical practice.Clinical neurophysiology practice · 2026Review
- The Off-Label Use of Selective Serotonin Reuptake Inhibitors for Sexual Behavior Management: Risks and Considerations.Healthcare (Basel, Switzerland) · 2025Review
- Exploration of the Possible Relationships Between Gut and Hypothalamic Inflammation and Allopregnanolone: Preclinical Findings in a Post-Finasteride Rat Model.Biomolecules · 2025Article
- Frequency of self-reported persistent post-treatment genital hypoesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US.Social psychiatry and psychiatric epidemiology · 2025Article
- Depression, selective serotonin reuptake inhibitors, and sexual wellbeing in assigned females: exploring the moderating role of sexual flexibility.The journal of sexual medicine · 2025Article
- The post-finasteride syndrome: possible etiological mechanisms and symptoms.International journal of impotence research · 2025Review
- Psychological and sexual functioning of persons suffering from post-SSRI sexual dysfunction - cases study.Current issues in personality psychology · 2025Article
- Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence.Epidemiology and psychiatric sciences · 2024Review
- A clinical guide to rare male sexual disorders.Nature reviews. Urology · 2024Review
- Talking about Sexuality in Stroke Individuals: The New Era of Sexual Rehabilitation.Journal of clinical medicine · 2023Article
- Acupuncture for premature ejaculation: a systematic review and meta-analysis.Sexual medicine · 2023Review
- The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction.Journal of endocrinological investigation · 2023Article
- Effects of major depression and bipolar disorder on erectile dysfunction: a two-sample mendelian randomization study.BMC medical genomics · 2023Article
- Cutting the First Turf to Heal Post-SSRI Sexual Dysfunction: A Male Retrospective Cohort Study.Medicines (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
37 authors at 20 institutions in 13 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA set of enduring conditions have been reported in the literature involving persistent sexual dysfunction after discontinuation of serotonin reuptake inhibiting antidepressants, 5 alpha-reductase inhibitors and isotretinoin.
objectiveTo develop diagnostic criteria for post-SSRI sexual dysfunction (PSSD), persistent genital arousal disorder (PGAD) following serotonin reuptake inhibitors, post-finasteride syndrome (PFS) and post-retinoid sexual dysfunction (PRSD).
methodsThe original draft was designed using data from two published case series (Hogan et al., 2014 and Healy et al., 2018), which represent the largest public collections of data on these enduring conditions. It was further developed with the involvement of a multidisciplinary panel of experts.
resultsA set of criteria were agreed upon for each of the above conditions. Features of PSSD, PFS and PRSD commonly include decreased genital and orgasmic sensation, decreased sexual desire and erectile dysfunction. Ancillary non-sexual symptoms vary depending on the specific condition but can include emotional blunting and cognitive impairment. PGAD presents with an almost mirror image of unwanted sensations of genital arousal or irritability in the absence of sexual desire. A new term, post-SSRI asexuality, is introduced to describe a dampening of sexual interest and pleasure resulting from a pre-natal or pre-teen exposure to a serotonin reuptake inhibitor.
conclusionsThese criteria will help in both clinical and research settings. As with all criteria, they will likely need modification in the light of developments.
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