Evidence map›Paper›PMID 34719434›Full record

ReviewJournal of Parkinson's disease2022

Preventing Parkinson's Disease: An Environmental Agenda.

Briana R De Miranda, Samuel M Goldman, Gary W Miller, J Timothy Greenamyre, E Ray Dorsey

Abstract readReview
In one paragraph

Review in Journal of Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  19. The Burden of Parkinson's Disease Based on the GBD 2021.International journal of public health · 2026
    Article
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Briana R De MirandaCenter for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Samuel M GoldmanDivision of Occupational and Environmental Medicine, San Francisco Veterans Affairs Health Care System, School of Medicine, University of California-San Francisco, San Francisco, CA, USA.
Gary W MillerDepartment of Environmnetal Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
J Timothy GreenamyrePittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
E Ray DorseyCenter for Health+Technology and Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.

Funding

Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
The Clinical Core will support in-person and virtual research visits for three of the four Research Projects at the University of Rochester Udall CenterP50NS108676 · NINDS · UNIVERSITY OF ROCHESTER · PI DORSEY, EARL RAY · 2018 to 2022
$9.2M
Vesicular Modulation of Dopamine Neuron ToxicityR01ES023839 · NIEHS · EMORY UNIVERSITY · PI MILLER, GARY W · 2015 to 2025
$5.0M
Environmental Mitochondrial Toxicants Cause LRRK2 Activation in Parkinson's DiseaseR00ES029986 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE MIRANDA, BRIANA · 2020 to 2022
$747k
NIEHS NIH HHS R00 ES029986NIEHS NIH HHS R01 ES023839NINDS NIH HHS P50 NS108676NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

Fueled by aging populations and continued environmental contamination, the global burden of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases, have multiple environmental and genetic influences but no approved disease modifying therapy. Additionally, efforts to prevent this debilitating disease have been limited. As numerous environmental contaminants (e.g., pesticides, metals, industrial chemicals) are implicated in PD, disease prevention is possible. To reduce the burden of PD, we have compiled preclinical and clinical research priorities that highlight both disease prediction and primary prevention. Though not exhaustive, the "PD prevention agenda" builds upon many years of research by our colleagues and proposes next steps through the lens of modifiable risk factors. The agenda identifies ten specific areas of further inquiry and considers the funding and policy changes that will be necessary to help prevent the world's fastest growing brain disease.

Indexed as

Parkinson DiseasePesticidesHumansPesticidesair pollutionchlorinated solventsclinical researchenvironmentmetalsParkinson’s diseasepesticidespreclinical research

Identifiers

PMID34719434
PMCPMC8842749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.