Evidence map›Paper›PMID 34719423›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2021

D-bifunctional protein deficiency caused by

Shu-Mei Yang, Chuan-Ding Cao, Ying Ding, Ming-Jie Wang, Shao-Jie Yue

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. One novelFrontiers in pediatrics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shu-Mei YangDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha 410008, China (Yue S-J, Email: shaojieyue@163.com).
Chuan-Ding CaoDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha 410008, China (Yue S-J, Email: shaojieyue@163.com).
Ying DingDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha 410008, China (Yue S-J, Email: shaojieyue@163.com).
Ming-Jie WangDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha 410008, China (Yue S-J, Email: shaojieyue@163.com).
Shao-Jie YueDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha 410008, China (Yue S-J, Email: shaojieyue@163.com).
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 15-day-old boy was admitted to the hospital due to repeated convulsions for 14 days. The main clinical manifestations were uncontrolled seizures, hypoergia, feeding difficulties, limb hypotonia, and bilateral hearing impairment. Clinical neurophysiology showed reduced brainstem auditory evoked potential on both sides and burst-suppression pattern on electroencephalogram. Measurement of very-long-chain fatty acids in serum showed that C26:0 was significantly increased. Genetic testing showed a pathogenic compound heterozygous mutation, c.101C>T(p.Ala34Val) and c.1448_1460del(p.Ala483Aspfs*37), in the

Indexed as

Muscle HypotoniaProtein DeficiencyGenetic TestingHumansInfant, NewbornMaleMutationPeroxisomal Multifunctional Protein-2HSD17B4 protein, humanPeroxisomal Multifunctional Protein-2D-bifunctional protein deficiencyNeonateSeizureVery-long-chain fatty acid

Identifiers

PMID34719423
PMCPMC8549635
OpenAlexW3210078400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.