Evidence map›Paper›PMID 34719317›Full record

ArticleGut microbes

The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses.

Ibrahim M Sayed, Stella-Rita Ibeawuchi, Dominique Lie, Mahitha Shree Anandachar, Rama Pranadinata, Manuela Raffatellu, Soumita Das

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Targeting of ELMO2 by thebioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Role of ELMO1 in inflammation and cancer-clinical implications.Cellular oncology (Dordrecht, Netherlands) · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ibrahim M SayedDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Stella-Rita IbeawuchiDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Dominique LieDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Mahitha Shree AnandacharDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Rama PranadinataDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Manuela RaffatelluDepartment of Pediatrics, Division of Host-Microbe Systems and Therapeutics, University of California San Diego, LA Jolla, CA, USA.
Soumita DasDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
University of California, San Diego · USChiba University · JP

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Macrophage Polarization in Response to Infections and InflammationR01AI155696 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA, SAHOO, DEBASHIS · 2020 to 2024
$4.9M
C3-Dependent Intracellular Killing in Innate Immunity and Bacterial PathogenesisR01AI145325 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, RAFFATELLU, MANUELA · 2019 to 2023
$3.1M
Innate responses following infection with enteric microbesR01DK107585 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2016 to 2020
$2.2M
Nutritional immunity during Salmonella infectionR01AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA · 2016 to 2020
$1.9M
Antimicrobial activity of Escherichia coli Nissle 1917 microcin MR21AI154644 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2020 to 2021
$440k
The host-microbe-metformin interplay in the aged gutR56AG069689 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2020 to 2020
$394k
Engulfment of enteric bacteria and the consequences for intestinal inflammationR56DK099275 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2014 to 2014
$221k
NCATS NIH HHS UL1 TR001442NIAID NIH HHS R01 AI126277NIAID NIH HHS R01 AI145325NIAID NIH HHS R01 AI155696NIAID NIH HHS R21 AI154644NIA NIH HHS R56 AG069689NIDDK NIH HHS R01 DK107585NIDDK NIH HHS R56 DK099275
6 · The paper itself

Abstract

Host engulfment protein ELMO1 generates intestinal inflammation following internalization of enteric bacteria. In

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBacterial ProteinsGastrointestinal MicrobiomeHost-Pathogen InteractionsHumansImmunity, InnateInterleukin-6MiceSalmonella InfectionsSalmonella typhimuriumTumor Necrosis Factor-alphaAdaptor Proteins, Signal TransducingBacterial ProteinsELMO1 protein, mouseInterleukin-6SifA protein, SalmonellaTumor Necrosis Factor-alphabacterial effectorscommensalsELMO1innate immune responseWxxxe motif

Identifiers

PMID34719317
PMCPMC8565811
OpenAlexW3209511990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.