Evidence map›Paper›PMID 34719151›Full record

ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2021

A Rare Lymphoproliferative Disease: Castleman Disease

Eren Gündüz, Nihal Özdemir, Şule Mine Bakanay, Sema Karakuş

Open access · diamondAbstract read
In one paragraph

Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Snapshot Look at Castleman Disease.Journal of cellular and molecular medicine · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Unicentric Castleman Disease: A Rare Diagnosis of Radiological and Histological Correlation.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  12. CT of Castleman disease in the mediastinum.Radiology case reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Eren GündüzEskişehir Osmangazi University Faculty of Medicine, Department of Hematology, Eskişehir, TurkeyORCID 0000-0002-7660-4092
Nihal Özdemirİstinye University Medical School, Department of Hematology, İstanbul, TurkeyORCID 0000-0002-3204-4353
Şule Mine BakanayAnkara Yıldırım Beyazıt University Medical School, Department of Hematology, Ankara, TurkeyORCID 0000-0003-3941-0368
Sema KarakuşBaşkent University Faculty of Medicine, Department of Hematology, Ankara, TurkeyORCID 0000-0001-7615-4581
Ankara Yıldırım Beyazıt University · TRBaşkent University · TREskişehir Osmangazi University · TRIstinye University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Castleman disease is a rare lymphoproliferative disease also known as angiofollicular lymph node hyperplasia. It is classified as hyaline vascular and plasmacytic variants histologically but characteristics of both types can coexist. Most unicentric cases of the disease are hyaline vascular while most multicentric cases are of the plasmacytic type. Although the pathogenesis is not completely understood, the role of interleukin (IL)-6 in unicentric disease and the roles of IL-6 and human herpes virus-8 in multicentric disease are well defined. Unicentric disease is typically localized and symptoms are minimal and treated locally. Multicentric disease is systemic and clinically characterized by generalized lymphadenopathy, splenomegaly, anemia, and systemic inflammatory symptoms. Systemic therapies are primarily given. Several malignant diseases including lymphomas, POEMS syndrome, follicular dendritic cell sarcomas, paraneoplastic pemphigus, Kaposi sarcoma, and amyloidosis can be associated with Castleman disease. In this paper, recent information about Castleman disease, which is a rare disease, is summarized.

Indexed as

Castleman DiseaseRare DiseasesHumansCastleman diseaseDiagnosisTreatment

Identifiers

PMID34719151
PMCPMC8656119
OpenAlexW3210133534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.