SynthesisJournal of cosmetic dermatology2021
Can SARS-CoV-2 vaccine increase the risk of reactivation of Varicella zoster? A systematic review.
Synthesis in Journal of cosmetic dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Herpesviruses reactivation following COVID-19 vaccination: a systematic review and meta-analysis.European journal of medical research · 2023Pooled it
- Can SARS-CoV-2 vaccine increase the risk of reactivation of Varicella zoster? A systematic review.Journal of cosmetic dermatology · 2021Pooled it
- Article
- mRNA vaccine boosters and impaired immune system response in immune compromised individuals: a narrative review.Clinical and experimental medicine · 2024Review
- Herpes Zoster Reactivation After mRNA and Adenovirus-Vectored Coronavirus Disease 2019 Vaccination: Analysis of National Health Insurance Database.The Journal of infectious diseases · 2023Article
- Herpes zoster in children during the COVID-19 pandemic in France: A retrospective multicenter observational study.Annales de dermatologie et de venereologie · 2023Observational
- Co-VAN study: COVID-19 vaccine associated neurological diseases- an experience from an apex neurosciences centre and review of the literature.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023Review
- Herpes Zoster Following COVID-19 Vaccine Booster.The American journal of case reports · 2023Article
- Herpes zoster ophthalmicus after COVID-19 vaccine booster in healthy younger adult: a case report.Clinical and experimental vaccine research · 2023Article
- Herpes Zoster and COVID-19 Vaccination: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2023Review
- Herpes zoster after COVID-19 vaccination, aspect of pain medicine: a retrospective, single-center study.Anesthesia and pain medicine · 2023Article
- Herpetic anterior uveitis following COVID-19 vaccines: a case series.Frontiers in medicine · 2023Article
- COVID-19 Vaccines, Effectiveness, and Immune Responses.International journal of molecular sciences · 2022Review
- Review
- Association study between herpes zoster reporting and mRNA COVID-19 vaccines (BNT162b2 and mRNA-1273).British journal of clinical pharmacology · 2022Article
- Zoster Meningitis in an Immunocompetent Child after COVID-19 Vaccination, California, USA.Emerging infectious diseases · 2022Article
- Adverse effects of COVID-19 vaccines and measures to prevent them.Virology journal · 2022Article
- A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination.Journal of Korean medical science · 2022Article
- Is COVID-19 infection triggering oral herpes zoster? A case report.SAGE open medical case reports · 2021Article
- Varicella Zoster Virus Reactivation in Patients with COVID-19: The Possible Immunological Basis.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
introductionAlthough the COVID-19 vaccination is deemed safe, exact incidence and nature if adverse effects, particularly dermatological ones, are still unknown.
objectiveTo describe the demographic, clinical, morphological characteristics, outcomes, and timing of development of herpes zoster to the various COVID-19 vaccines. And to identify on whether COVID-19 vaccine has temporal relationship between development of herpes zoster (HZ).
methodsWe have performed a systemic review of articles from PubMed and Embase using MeSH and keywords like "Shingles," "Herpes zoster," "Varicella zoster," "COVID-19," "Vaccine," "SARS-CoV-2." No filters including country of publication, language, type of articles were applied. Individual case report references were filtered for any pertinent cases.
resultsA total of 54 cases consisting of 27 male and 27 female patients have been reported. There were cases with known risk factors for herpes zoster, which included age more than 50 years (n = 36), immunological disorders (n = 10), chronic disease (n = 25), metabolic disorder (n = 13), malignancy (n = 4), and psychiatric disorder (n = 2). The mean (SD) period between development of herpes zoster and COVID-19 vaccination was 7.64 (6.92) days. Majority of the cases were from the high-income and/or middle-income countries. 86.27% of the cases of HZ were reported due to mRNA vaccine. Thirty-six patients 36/45 (80%) developed herpes zoster following the priming dose of COVID-19 vaccine among those who received mRNA vaccine.
conclusionWe could not establish definite link but there may be possible association between COVID-19 vaccine and shingles. Large-scale studies may help to understand the cause-effect relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.