ArticleEnvironmental science and pollution research international2022
Propolis nanoparticles relieved the impacts of glyphosate-induced oxidative stress and immunosuppression in Nile tilapia.
Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Review
- Melittin Nanoparticles Mitigate Glyphosate-Induced Nephrotoxicity via Cytokine Modulation and Bax/Nrf2 Pathways.Biomedicines · 2025Article
- Oxidative Stress and Neurotoxicity Biomarkers in Fish Toxicology.Antioxidants (Basel, Switzerland) · 2025Review
- Blood Biochemical Biomarkers in Fish Toxicology-A Review.Animals : an open access journal from MDPI · 2025Review
- Glyphosate-induced liver and kidney dysfunction, oxidative stress, immunosuppression in Nile tilapia, but ginger showed a protection role.Veterinary research communications · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk of the waterborne toxicity caused by herbicides threatens the aquatic environment. In this study, propolis nanoparticles were shown to relieve the impacts of glyphosate-induced oxidative stress and immunosuppression in Nile tilapia. The control group was fed a basal diet and maintained in a glyphosate-free water (control). Simultaneously, the other three groups were exposed to sublethal concentrations of glyphosate (0.6 mg/L) and fed diets containing 0 and 10 g propolis and 10 g propolis nanoparticles for 4 weeks. Nile tilapia exposed to glyphosate for 2 and 4 weeks exhibited a significant increase in serum alanine aminotransferase, aspartate aminotransferase, urea, and creatinine values compared to the control. After 2 and 4 weeks, fish exposed to glyphosate who were not fed propolis and propolis nanoparticles showed a significant reduction in total protein, albumin, and globulin levels, lysozyme activity, and total immunoglobulin levels. Nile tilapia exposed to glyphosate displayed a significant increase in blood glucose and cortisol concentrations after 2 and 4 weeks. Furthermore, liver and gill tissues from fish exposed to glyphosate exhibited a significant increase in malondialdehyde (MDA) concentrations. Conversely, a statistically significant decrease was observed in the liver and gill MDA levels and AChE activity of the groups treated with propolis and propolis nanoparticles compared to the groups exposed to glyphosate and fed the basal diet. Fish exposed to glyphosate for 2 and 4 weeks showed a significant decrease (p < 0.05) in hepatic and gill glutathione (GSH) concentration and white blood cell and red blood cell counts compared to the control group. Meanwhile, these parameters in groups fed propolis and propolis nanoparticles were markedly ameliorated compared to exposed fish fed the basal diet. Dietary supplementation of propolis nanoparticles is superior to supplementation of propolis in the normal form for protecting Nile tilapia from glyphosate toxicity.
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