Evidence map›Paper›PMID 34718917›Full record

ArticleNeurosurgical review2022

Systemic immune-inflammation index predicts the outcome after aneurysmal subarachnoid hemorrhage.

Fushu Luo, Yuanyou Li, Yutong Zhao, Mingjiang Sun, Qiuguang He, Rong Wen, Zongyi Xie

Abstract read
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In one paragraph

Article in Neurosurgical review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fushu LuoDepartment of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yuanyou LiDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
Yutong ZhaoDepartment of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Mingjiang SunDepartment of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Qiuguang HeDepartment of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Rong WenDepartment of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Zongyi XieDepartment of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. zyxieneuro2013@yahoo.com.ORCID http://orcid.org/0000-0003-2991-1732
Dalian Medical University · CNSichuan University · CN

Funding

chongqing science and health joint project 2020GDRC006venture and innovation support program for chongqing overseas returnees CX2019156Wellcome Trust 201959
6 · The paper itself

Abstract

Systemic inflammatory response is closely related to the pathogenesis and prognosis in critical patients. Recently, systemic immune-inflammation index (SII), an indicator of systemic inflammatory response, was proved to predict the outcome in cancerous and non-cancerous diseases. The aim of this study is to investigate the association between SII on admission and 6-month outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). The clinical data and prognosis of 76 patients with aSAH were analyzed. The 6-month outcome was assessed by the modified Rankin scale(mRS). The unfavorable outcome was defined as mRS score ≥ 3. In addition, multivariate analysis was conducted to investigate factors independently associated with the favorable outcome. Receiver operating characteristic (ROC) curve analysis was undertaken to identify the best cut-off value of SII for the discriminate between favorable and unfavorable outcome in these patients. Thirty-six patients (47.4%) in our study had an unfavorable outcome (mRS ≥ 3) at 6 months, and twenty-four (66.7%) of them were in the high-SII group. A significantly higher SII on admission was observed in patients with unfavorable functional outcome at 6 months. Binary logistic regression analysis showed that there was an independent association between SII on admission and 6-month clinical outcome (adjusted OR = 4.499, 95%CI: 1.242-16.295, P < 0.05). The AUC of the SII for predicting unfavorable outcome was 0.692 (95% CI: 0.571-0.814, P < 0.05). Systemic immune-inflammation index (SII) could be a novel independent prognostic factor for aSAH patients at the early stage of the disease.

Indexed as

Subarachnoid HemorrhageHumansInflammationPrognosisRetrospective StudiesROC CurveAneurysmal subarachnoid hemorrhageSerological indicatorSystemic immune-inflammation indexSystemic inflammatory response

Identifiers

PMID34718917
OpenAlexW3181294202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.