Observational studyWorld journal of surgery2022
Patients with Crohn's Disease Undergoing Abdominal Surgery: Clinical and Prognostic Evaluation Based on a Single-Center Cohort in China.
Observational study in World journal of surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Prognostic models for predicting postoperative recurrence in Crohn's disease: a systematic review and critical appraisal.Frontiers in immunology · 2023Pooled it
- Association of appendectomy with disease phenotype and clinical course in Crohn's disease: results from two cohorts.Techniques in coloproctology · 2025Article
- Machine learning for temporary stoma after intestinal resection in surgical decision-making of Crohn's disease.BMC gastroenterology · 2025Article
- Characteristics and surgical outcomes of small intestine-rectal fistulas in patients with Crohn's disease.International journal of colorectal disease · 2025Article
- Characterization of risk factors and postoperative pharmacological prophylaxis patterns affecting re-resection in Crohn's disease with surgical recurrence.International journal of colorectal disease · 2025Article
- Predicting short-term major postoperative complications in intestinal resection for Crohn's disease: A machine learning-based study.World journal of gastrointestinal surgery · 2024Article
- Differences in the risk of clinical failure between thiopurine and methotrexate in bio-naïve patients with Crohn's disease: a Korean nationwide population-based study.Therapeutic advances in gastroenterology · 2024Article
- Experience of providing care to a family member with Crohn's disease and a temporary stoma: A qualitative study.Heliyon · 2023Article
- Temporal trends in surgery for Crohn's disease: a ten-year single-center retrospective study.International journal of colorectal disease · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence and prevalence of Crohn's disease (CD) are increasing in China, but there are few reports on the characteristics of patients requiring abdominal surgery. This study aimed to evaluate the clinical characteristics of these patients and the potential risk factors for postoperative complications and surgical recurrence.
methodsIn this observational, retrospective single-center cohort analysis, patients with CD who had undergone at least one abdominal surgery at our center from 2007 to 2020 were included. Data were collected from a prospectively maintained database. Clinical factors were assessed by logistic regression models, Kaplan-Meier methods, and Cox proportional hazards regression models. The predictive accuracy of the nomogram was determined by a concordance index (C-index) and calibration curve and was validated using bootstrap resampling.
resultsIn the 1639 patients, clinical characteristics were evaluated. In a multivariable logistic regression model, penetrating behavior (P = 0.002), emergency surgery (P = 0.010), and smoking status (P = 0.015) were significantly associated with an increased risk of postoperative septic complications. In contrast, staged surgery (P = 0.009) was inversely associated with postoperative complications. Upper gastrointestinal disease (P = 0.042), penetrating behavior (P = 0.027), emergency at initial surgery (P < 0.001) were significantly associated with an increased risk of surgical recurrence after the index surgery in our Cox regression model, whereas staged surgery (P = 0.036) was significantly associated with a decreased risk. The C-index of the nomogram for predicting recurrence was 0.744 (P = 0.015), and calibration curves showed good agreement between predictions of 3, 5, and 10 years of recurrence and actual observations.
conclusionsThere are several disease- and surgery-associated risk factors of postoperative adverse outcomes in patients with CD undergoing abdominal surgery. This is important in optimizing the management of CD which has evolved into a global disease with rising prevalence in newly industrialized countries including China.
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