ArticleSleep2022
Associations of sleep measures with neural activations accompanying fear conditioning and extinction learning and memory in trauma-exposed individuals.
Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Preferential consolidation of emotional reactivity during sleep: A systematic review and meta-analysis.Frontiers in behavioral neuroscience · 2022Pooled it
- Slow Oscillation-Sleep Spindle Coupling Is Associated With Expectancy Measures of Fear Extinction Retention in Trauma-Exposed Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- A neural signature of sleep deprivation in the human brain.Nature communications · 2026Article
- Mechanistic Non-Response After Psychotherapy for Anxiety Disorders: A Maintenance-Mechanism-Based Clinical Taxonomy.Journal of clinical medicine · 2026Review
- Usability, adherence and efficacy of coach-augmented dHealth cognitive behavioural therapy for insomnia in South African sexual assault survivors: a pilot study.Frontiers in psychiatry · 2026Article
- A systematic review of spontaneous recovery in human fear conditioning.Frontiers in behavioral neuroscience · 2026Review
- Local and network neural activations and their associations with sleep parameters during threat conditioning and extinction in persons with Generalized Anxiety Disorder with and without Insomnia Disorder.bioRxiv : the preprint server for biology · 2025Article
- Within-person associations of daily activity to sleep actigraphy following trauma: Explicating a novel index of risk for major depressive disorder and posttraumatic stress disorder.Journal of psychopathology and clinical science · 2025Article
- The relation between passively collected data and PTSD: a systematic review and meta-analysis.NPJ digital medicine · 2025Article
- Slow oscillation-sleep spindle coupling is associated with fear extinction retention in trauma-exposed individuals.bioRxiv : the preprint server for biology · 2025Article
- The role of objective sleep in implicit and explicit affect regulation: A comprehensive review.Neurobiology of stress · 2024Article
- REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals.bioRxiv : the preprint server for biology · 2024Article
- Comparison of autonomic reactivity to trauma and nightmare imagery: A Pilot Study.Sleep advances : a journal of the Sleep Research Society · 2024Article
- The influence of sleep on fear extinction in trauma-related disorders.Neurobiology of stress · 2023Article
- Revisiting sex differences in the acquisition and extinction of threat conditioning in humans.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Temporally and anatomically specific contributions of the human amygdala to threat and safety learning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Morning blue light treatment improves sleep complaints, symptom severity, and retention of fear extinction memory in post-traumatic stress disorder.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesSleep disturbances increase risk of posttraumatic stress disorder (PTSD). Sleep effects on extinction may contribute to such risk. Neural activations to fear extinction were examined in trauma-exposed participants and associated with sleep variables.
methodsIndividuals trauma-exposed within the past 2 years (N = 126, 63 PTSD) completed 2 weeks actigraphy and sleep diaries, three nights ambulatory polysomnography and a 2-day fMRI protocol with Fear-Conditioning, Extinction-Learning and, 24 h later, Extinction-Recall phases. Activations within the anterior cerebrum and regions of interest (ROI) were examined within the total, PTSD-diagnosed and trauma-exposed control (TEC) groups. Sleep variables were used to predict activations within groups and among total participants. Family wise error was controlled at p < 0.05 using nonparametric analysis with 5,000 permutations.
resultsInitially, Fear Conditioning activated broad subcortical and cortical anterior-cerebral regions. Within-group analyses showed: (1) by end of Fear Conditioning activations decreased in TEC but not PTSD; (2) across Extinction Learning, TEC activated medial prefrontal areas associated with emotion regulation whereas PTSD did not; (3) beginning Extinction Recall, PTSD activated this emotion-regulatory region whereas TEC did not. However, the only between-group contrast reaching significance was greater activation of a hippocampal ROI in TEC at Extinction Recall. A greater number of sleep variables were associated with cortical activations in separate groups versus the entire sample and in PTSD versus TEC.
conclusionsPTSD nonsignificantly delayed extinction learning relative to TEC possibly increasing vulnerability to pathological anxiety. The influence of sleep integrity on brain responses to threat and extinction may be greater in more symptomatic individuals.
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