ArticlePlant physiology2022
Biosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Meta-analysis and co-expression analysis revealed stable QTL and candidate genes conferring resistances to Fusarium and Gibberella ear rots while reducing mycotoxin contamination in maize.Frontiers in plant science · 2022Pooled it
- Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Climate Warming and Plant Disease: Mechanistic Insights Into Pathogenic Stress Resilience.Plant, cell & environment · 2026Review
- Plant Flavonoids: Biosynthesis, Regulation, and Roles in Biotic and Abiotic Stresses.Plant, cell & environment · 2026Review
- Evolutionary origin of neohesperidoside, a bitter metabolite, and its potential role in biotic defense and citrus dissemination.Plant communications · 2026Article
- ZmWRKY92-Mediated miR169s/NF-YA13 Module Confers Maize Resistance to Bipolaris maydis by Activating Flavonoid Biosynthesis.Molecular plant pathology · 2026Article
- The Involvement of Glycerophospholipids in Susceptibility of Maize to Gibberella Root Rot Revealed by Comparative Metabolomics and Mass Spectrometry Imaging Joint Analysis.Plants (Basel, Switzerland) · 2025Article
- Ripening-Related Changes in Color and Bioactive Compounds ofFoods (Basel, Switzerland) · 2025Article
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- The distribution of catechins and their derivatives among 114Food chemistry: X · 2025Article
- Review
- Regulation of maize growth and immunity by ZmSKI3-mediated RNA decay and post-transcriptional gene silencing.Journal of integrative plant biology · 2024Article
- Herbal materials used as soil amendments alleviate root rot of Panax ginseng.Scientific reports · 2024Article
- Beyond pathways: Accelerated flavonoids candidate identification and novel exploration of enzymatic properties using combined mapping populations of wheat.Plant biotechnology journal · 2024Article
- Identification of OneInternational journal of molecular sciences · 2024Article
- DiverseHorticulture research · 2023Article
- Regioselective stilbene O-methylations in Saccharinae grasses.Nature communications · 2023Article
- Decoding Metabolic Reprogramming in Plants under Pathogen Attacks, a Comprehensive Review of Emerging Metabolomics Technologies to Maximize Their Applications.Metabolites · 2023Review
- Recent advancements in multifaceted roles of flavonoids in plant-rhizomicrobiome interactions.Frontiers in plant science · 2023Review
- Stressing the importance of plant specialized metabolites: omics-based approaches for discovering specialized metabolism in plant stress responses.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Fungal infection of grasses, including rice (Oryza sativa), sorghum (Sorghum bicolor), and barley (Hordeum vulgare), induces the formation and accumulation of flavonoid phytoalexins. In maize (Zea mays), however, investigators have emphasized benzoxazinoid and terpenoid phytoalexins, and comparatively little is known about flavonoid induction in response to pathogens. Here, we examined fungus-elicited flavonoid metabolism in maize and identified key biosynthetic enzymes involved in the formation of O-methylflavonoids. The predominant end products were identified as two tautomers of a 2-hydroxynaringenin-derived compound termed xilonenin, which significantly inhibited the growth of two maize pathogens, Fusarium graminearum and Fusarium verticillioides. Among the biosynthetic enzymes identified were two O-methyltransferases (OMTs), flavonoid OMT 2 (FOMT2), and FOMT4, which demonstrated distinct regiospecificity on a broad spectrum of flavonoid classes. In addition, a cytochrome P450 monooxygenase (CYP) in the CYP93G subfamily was found to serve as a flavanone 2-hydroxylase providing the substrate for FOMT2-catalyzed formation of xilonenin. In summary, maize produces a diverse blend of O-methylflavonoids with antifungal activity upon attack by a broad range of fungi.
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