Evidence map›Paper›PMID 34718729›Full record

ArticleNucleic acids research2022

Complex Portal 2022: new curation frontiers.

Birgit H M Meldal, Livia Perfetto, Colin Combe, Tiago Lubiana, João Vitor Ferreira Cavalcante, Hema Bye-A-Jee, Andra Waagmeester, Noemi Del-Toro, Anjali Shrivastava, Elisabeth Barrera and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 67 citations in OpenAlex.

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  12. What Have Data Standards Ever Done for Us?Molecular & cellular proteomics : MCP · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 7 countries.

Birgit H M MeldalEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0003-4062-6158
Livia PerfettoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Colin CombeWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.
Tiago LubianaDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Av. Professor Lineu Prestes 580, CEP 05508-000 São Paulo SP, Brasil.
João Vitor Ferreira CavalcanteBioinformatics Multidisciplinary Environment (BioME), Digital Metropolis Institute, Federal University of Rio Grande do Norte, Av. Odilon Gomes de Lima 1722, Capim Macio, 59078-400 Natal/RN, Brasil.
Hema Bye-A-JeeEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Andra WaagmeesterMicelio, Veltwijcklaan 305, 2180 Ekeren, Belgium.ORCID 0000-0001-9773-4008
Noemi Del-ToroEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0001-5272-7613
Anjali ShrivastavaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Elisabeth BarreraEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Edith WongDepartment of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA.
Bernhard MlecnikLaboratory of Integrative Cancer Immunology, INSERM, 75006 Paris, France.ORCID 0000-0002-3345-1030
Gabriela BindeaLaboratory of Integrative Cancer Immunology, INSERM, 75006 Paris, France.ORCID 0000-0001-6013-6645
Kalpana PanneerselvamEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Egon WillighagenDept of Bioinformatics - BiGCaT, NUTRIM, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands.ORCID 0000-0001-7542-0286
Juri RappsilberWellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.
Pablo PorrasEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0002-8429-8793
Henning HermjakobEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0001-8479-0262
Sandra OrchardEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.ORCID 0000-0002-8878-3972
European Bioinformatics Institute · GBInserm · FRWellcome Centre for Cell Biology · GBMaastricht University · NLStanford University · USUniversidade de São Paulo · BRUniversidade Federal do Rio Grande do Norte · BR

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
UniProt - Text Mining and Large Language models to Enhance Functional Annotation in UniProt of Protein Variants Associated with Alzheimer's DiseaseU24HG007822 · NHGRI · GEORGETOWN UNIVERSITY · PI Alex Bateman, Alan James Bridge · 2018 to 2026
$53.0M
Resource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, PAUL D. · 2012 to 2021
$34.7M
Genomic Resource for the Yeast SaccharomycesU24HG001315 · NHGRI · STANFORD UNIVERSITY · PI Stacia Engel, Gavin J Sherlock · 2021 to 2026
$10.9M
PRO: A Protein Ontology in Open Biomedical OntologiesR01GM080646 · NIGMS · UNIVERSITY OF DELAWARE · PI WU, CATHY H. · 2007 to 2018
$8.9M
The Gene Wiki: Community intelligence applied to gene annotationR01GM089820 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SU, ANDREW I · 2010 to 2021
$5.2M
NCI NIH HHSNEI NIH HHSNHGRI NIH HHS U24 HG001315NHGRI NIH HHS U24 HG007822NHGRI NIH HHS U41 HG002273NHGRI NIH HHS U41HG002273NHLBI NIH HHSNIA NIH HHSNIDDK NIH HHSNIGMS NIH HHS P20 GM103446NIGMS NIH HHS R01 GM080646NIGMS NIH HHS R01GM080646NIGMS NIH HHS R01 GM089820NIMH NIH HHS U24HG007822Wellcome Trust 203149Wellcome Trust 218294
6 · The paper itself

Abstract

The Complex Portal (www.ebi.ac.uk/complexportal) is a manually curated, encyclopaedic database of macromolecular complexes with known function from a range of model organisms. It summarizes complex composition, topology and function along with links to a large range of domain-specific resources (i.e. wwPDB, EMDB and Reactome). Since the last update in 2019, we have produced a first draft complexome for Escherichia coli, maintained and updated that of Saccharomyces cerevisiae, added over 40 coronavirus complexes and increased the human complexome to over 1100 complexes that include approximately 200 complexes that act as targets for viral proteins or are part of the immune system. The display of protein features in ComplexViewer has been improved and the participant table is now colour-coordinated with the nodes in ComplexViewer. Community collaboration has expanded, for example by contributing to an analysis of putative transcription cofactors and providing data accessible to semantic web tools through Wikidata which is now populated with manually curated Complex Portal content through a new bot. Our data license is now CC0 to encourage data reuse. Users are encouraged to get in touch, provide us with feedback and send curation requests through the 'Support' link.

Indexed as

Databases, ProteinCoronavirusDatabases, ChemicalData CurationData VisualizationEnzymesEscherichia coliHumansInternational CooperationMolecular Sequence AnnotationMultiprotein ComplexesUser-Computer InterfaceEnzymesMultiprotein Complexes

Identifiers

PMID34718729
PMCPMC8689886
OpenAlexW3210712771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.