Evidence map›Paper›PMID 34718710›Full record

ArticleNucleic acids research2022

The Natural Products Atlas 2.0: a database of microbially-derived natural products.

Jeffrey A van Santen, Ella F Poynton, Dasha Iskakova, Emily McMann, Tyler A Alsup, Trevor N Clark, Claire H Fergusson, David P Fewer, Alison H Hughes, Caitlin A McCadden and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 306 citations in OpenAlex.

  1. The Oxytetracycline ProducerInternational journal of molecular sciences · 2026
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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 5 countries.

Jeffrey A van SantenDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.ORCID 0000-0002-5424-804X
Ella F PoyntonDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Dasha IskakovaDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Emily McMannDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Tyler A AlsupDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Trevor N ClarkDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
Claire H FergussonDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
David P FewerDepartment of Microbiology, University of Helsinki, 00014 Helsinki, Finland.
Alison H HughesStrathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4 0RE, UK.
Caitlin A McCaddenDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Jonathan ParraStrathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4 0RE, UK.
Sylvia SoldatouMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UK.
Jeffrey D RudolfDepartment of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Elisabeth M-L JanssenDepartment of Environmental Chemistry, Swiss Federal Institute of Aquatic Science and Technology (Eawag), 8600 Duebendorf, Switzerland.
Katherine R DuncanStrathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow G4 0RE, UK.
Roger G LiningtonDepartment of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.ORCID 0000-0003-1818-4971
Simon Fraser University · CAUniversity of Florida · USUniversity of Strathclyde · GBSwiss Federal Institute of Aquatic Science and Technology · CHUniversity of Aberdeen · GBUniversity of Helsinki · FI

Funding

Cytochrome P450 Enzymes from Streptomyces: Diverse Biocatalysts in Natural Products BiosynthesisR00GM124461 · NIGMS · UNIVERSITY OF FLORIDA · PI RUDOLF, JEFFREY DANIEL · 2019 to 2021
$747k
Cytochrome P450 Enzymes from Streptomyces: Diverse Biocatalysts in Natural Products BiosynthesisK99GM124461 · NIGMS · SCRIPPS FLORIDA · PI RUDOLF, JEFFREY DANIEL · 2017 to 2017
$90k
NIGMS NIH HHS K99 GM124461NIGMS NIH HHS R00 GM124461
6 · The paper itself

Abstract

Within the natural products field there is an increasing emphasis on the study of compounds from microbial sources. This has been fuelled by interest in the central role that microorganisms play in mediating both interspecies interactions and host-microbe relationships. To support the study of natural products chemistry produced by microorganisms we released the Natural Products Atlas, a database of known microbial natural products structures, in 2019. This paper reports the release of a new version of the database which includes a full RESTful application programming interface (API), a new website framework, and an expanded database that includes 8128 new compounds, bringing the total to 32 552. In addition to these structural and content changes we have added full taxonomic descriptions for all microbial taxa and have added chemical ontology terms from both NP Classifier and ClassyFire. We have also performed manual curation to review all entries with incomplete configurational assignments and have integrated data from external resources, including CyanoMetDB. Finally, we have improved the user experience by updating the Overview dashboard and creating a dashboard for taxonomic origin. The database can be accessed via the new interactive website at https://www.npatlas.org.

Indexed as

Databases, FactualSoftwareBacteriaBiological ProductsClassificationFungiHost Microbial InteractionsHumansUser-Computer InterfaceBiological Products

Identifiers

PMID34718710
PMCPMC8728154
OpenAlexW3210489033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.