ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Life-space Mobility in Older Men: The Role of Perceived Physical and Mental Fatigability.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Prevalence of fatigue and perceived fatigability in older adults: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Evaluation of the construct validity of the Michigan Fatigability Index (MIFI) short forms: a cross-sectional survey study.Journal of patient-reported outcomes · 2026Article
- Association between subjective cognitive decline and life-space mobility in a community-based elderly adults: a moderated mediation model of depression and perceived social support.Aging clinical and experimental research · 2025Article
- The association of physical activity with perceived fatigability among community-dwelling older adults aged ≥60 years in regional China.Preventive medicine reports · 2025Article
- Development of self-report measures of physical, mental, and emotional fatigability: the michigan fatigability index (MIFI).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Association between social support and life space mobility in older patients after percutaneous coronary intervention: mediating roles of health literacy and intrinsic capacity.Frontiers in public health · 2025Observational
- Opportunities and shortcomings of AI for spatial epidemiology and health disparities research on aging and the life course.Health & place · 2024Article
- Associations of depression and perceived physical fatigability with white matter integrity in older adults.Psychiatry research. Neuroimaging · 2024Article
- Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Role of Perceived Physical and Mental Fatigability Severity on Prospective, Recurrent, and Injurious Fall Risk in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Dual Roles of Cardiorespiratory Fitness and Fatigability in the Life-Space Mobility of Older Adults: The Study of Muscle, Mobility and Aging (SOMMA).The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Measuring and Understanding the Health Impact of Greater Fatigability in Older Adults: A Call to Action and Opportunities.Fatigue : biomedicine, health & behavior · 2023Article
- Prospective Associations Between Physical Activity and Perceived Fatigability in Older Men: Differences by Activity Type and Baseline Marital Status.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Changes in Objectively Measured Physical Activity Are Associated With Perceived Physical and Mental Fatigability in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPhysical performance and fatigue can limit mobility within the larger environment (life-space mobility). It is unknown whether perceived fatigability, self-reported fatigue anchored to activity intensity and duration, is independently associated with life-space.
methodsWe assessed this cross-sectionally in Visit 4 (2014-2016) of the Osteoporotic Fractures in Men Study (MrOS; N = 1 672, Age: Mean = 84.2 ± 4.0 years). The Pittsburgh Fatigability Scale (PFS, range: 0-50; higher = greater fatigability) measured physical (Mean = 16.1 ± 9.4) and mental fatigability (Mean = 7.5 ± 7.9). Life Space Assessment scores incorporated level, frequency, and assistance used for life-space mobility (range: 0-120, higher = greater life-space mobility; life-space constriction: inability to leave neighborhood without assistance). Separate multiple linear and logistic regressions for physical and mental fatigability were sequentially adjusted for demographic, health/lifestyle, and performance measures.
resultsThe mean life-space mobility score was 84.6 ± 21.8, and 18% (n = 296) of men had life-space constriction. Higher physical and mental fatigability were both associated with lower life-space mobility in models adjusted for health and lifestyle factors (Physical PFS: B = -2.37, 95% confidence interval [CI]: [-3.39, -1.35]; Mental PFS: B = -1.79, 95% CI: [-2.73, -0.84]). Men with higher fatigability also had increased risk of life-space constriction (Physical PFS: OR = 1.59, 95% CI: [1.32, 1.92]; Mental PFS: OR = 1.25, 95% CI: [1.08, 1.46]). Associations were larger in magnitude for physical versus mental fatigability. Adjusting for physical performance measures more strongly attenuated associations for physical compared to mental fatigability.
conclusionsFatigability is linked with real-world mobility in older men, independent of their physical health. This association may be driven by separate physical and cognitive mechanisms worth examining further in longitudinal studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.