ArticleGenetics2021
The correlation of substitution effects across populations and generations in the presence of nonadditive functional gene action.
Article in Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- In silico prediction of variant effects: promises and limitations for precision plant breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Multi-population GWAS detects robust marker associations in a newly established six-rowed winter barley breeding program.Heredity · 2025Article
- Changes in allele frequencies and genetic architecture due to selection in two pig populations.Genetics, selection, evolution : GSE · 2024Article
- Article
- Temporal dynamics of genetic parameters and SNP effects for performance and disorder traits in poultry undergoing genomic selection.Journal of animal science · 2024Article
- Investigating the impact of non-additive genetic effects in the estimation of variance components and genomic predictions for heat tolerance and performance traits in crossbred and purebred pig populations.BMC genomic data · 2023Article
- The long-term effects of genomic selection: 2. Changes in allele frequencies of causal loci and new mutations.Genetics · 2023Article
- The importance of historically popular sires on the accuracy of genomic predictions of young animals in the US Holstein population.JDS communications · 2023Article
- Review
- Derivation of indirect predictions using genomic recursions across generations in a broiler population.Journal of animal science · 2023Article
- Genome-wide marker effect heterogeneity is associated with a large effect dormancy locus in winter malting barley.The plant genome · 2022Article
- Genomic prediction with whole-genome sequence data in intensely selected pig lines.Genetics, selection, evolution : GSE · 2022Article
- High genetic correlation for milk yield across Manech and Latxa dairy sheep from France and Spain.JDS communications · 2022Article
- Article
- Perspectives on Applications of Hierarchical Gene-To-Phenotype (G2P) Maps to Capture Non-stationary Effects of Alleles in Genomic Prediction.Frontiers in plant science · 2021Article
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Authors and funding
4 authors.
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Abstract
Allele substitution effects at quantitative trait loci (QTL) are part of the basis of quantitative genetics theory and applications such as association analysis and genomic prediction. In the presence of nonadditive functional gene action, substitution effects are not constant across populations. We develop an original approach to model the difference in substitution effects across populations as a first order Taylor series expansion from a "focal" population. This expansion involves the difference in allele frequencies and second-order statistical effects (additive by additive and dominance). The change in allele frequencies is a function of relationships (or genetic distances) across populations. As a result, it is possible to estimate the correlation of substitution effects across two populations using three elements: magnitudes of additive, dominance, and additive by additive variances; relationships (Nei's minimum distances or Fst indexes); and assumed heterozygosities. Similarly, the theory applies as well to distinct generations in a population, in which case the distance across generations is a function of increase of inbreeding. Simulation results confirmed our derivations. Slight biases were observed, depending on the nonadditive mechanism and the reference allele. Our derivations are useful to understand and forecast the possibility of prediction across populations and the similarity of GWAS effects.
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