Evidence map›Paper›PMID 34718460›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2022

Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex.

Evan M Gordon, Timothy O Laumann, Scott Marek, Dillan J Newbold, Jacqueline M Hampton, Nicole A Seider, David F Montez, Ashley M Nielsen, Andrew N Van, Annie Zheng and 9 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 60 citations in OpenAlex.

  1. Trial
  2. Article
  3. Medial prefrontal-thalamic white matter microstructure is associated with harm avoidance in OCD: a discovery and transdiagnostic replication study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Article
  5. Human striatal population state dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Abnormal ventromedial-to-dorsolateral hierarchical topography of striatal circuits in cocaine use disorder and its modulations by brain stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  14. Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
  16. The brain's action-mode network.Nature reviews. Neuroscience · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Evan M GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-2276-5237
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Scott MarekDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dillan J NewboldDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jacqueline M HamptonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-0175-5360
Nicole A SeiderDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
David F MontezDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ashley M NielsenInstitute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL 60611, USA.
Andrew N VanDepartment of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63110, USA.
Annie ZhengDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ryland MillerDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua S SiegelDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-5752-3641
Benjamin P KayDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Abraham Z SnyderDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Deanna J GreeneDepartment of Cognitive Science, University of California San Diego, La Jolla, CA 92093, USA.
Bradley L SchlaggarKennedy Krieger Institute, Baltimore, MD 21205, USA.
Steven E PetersenDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Steven M NelsonDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.
Nico U F DosenbachDepartment of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · USCognizant (United States) · USKennedy Krieger Institute · USNorthwestern University · USUniversity of Maryland, Baltimore · USUniversity of Minnesota · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI AN, HONGYU · 2016 to 2019
$2.4M
Washington University Psychiatry Residency Research Education ProgramR25MH112473 · NIMH · WASHINGTON UNIVERSITY · PI NURI B FARBER, Timothy Eric Spiegel · 2018 to 2026
$1.6M
Concussion and Attention-Deficit/Hyperactivity Disorder: Investigating the relationship between cognitive outcome, prescription stimulants, and functional MRI biomarkers in the ABCD study.K23NS123345 · NINDS · WASHINGTON UNIVERSITY · PI Benjamin Paul Kay · 2022 to 2026
$948k
PEDIATRIC BRAIN INJURY RECOVERY VIA USE-DRIVEN FUNCTIONAL NETWORK REORGANIZATIONK23NS088590 · NINDS · WASHINGTON UNIVERSITY · PI DOSENBACH, NICO · 2015 to 2019
$886k
PREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATAK01MH104592 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2014 to 2018
$723k
Dynamics in resting and task-based functional connectivityF30MH100872 · NIMH · WASHINGTON UNIVERSITY · PI LAUMANN, TIMOTHY OTTO · 2013 to 2016
$145k
Human network plasticity caused by disuseF31NS110332 · NINDS · WASHINGTON UNIVERSITY · PI NEWBOLD, DILLAN JACOB · 2019 to 2021
$94k
Individual-specific functional subdivisions of the human hippocampus in children revealed by precision functional mappingF31MH123091 · NIMH · WASHINGTON UNIVERSITY · PI ZHENG, ANNIE · 2021 to 2022
$46k
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIMH NIH HHS F30 MH100872NIMH NIH HHS F31 MH123091NIMH NIH HHS K01 MH104592NIMH NIH HHS R25 MH112473NIMH NIH HHS T32 MH100019NINDS NIH HHS F31 NS110332NINDS NIH HHS K23 NS088590NINDS NIH HHS K23 NS123345NINDS NIH HHS P30 NS098577
6 · The paper itself

Abstract

The striatum and cerebral cortex are interconnected via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate corticostriatal connections can be precisely mapped using invasive tract-tracing. However, noninvasive human research has not mapped these connections with anatomical precision, limited in part by the practice of averaging neuroimaging data across individuals. Here we utilized highly sampled resting-state functional connectivity MRI for individual-specific precision functional mapping (PFM) of corticostriatal connections. We identified ten individual-specific subnetworks linking cortex-predominately frontal cortex-to striatum, most of which converged with nonhuman primate tract-tracing work. These included separable connections between nucleus accumbens core/shell and orbitofrontal/medial frontal gyrus; between anterior striatum and dorsomedial prefrontal cortex; between dorsal caudate and lateral prefrontal cortex; and between middle/posterior putamen and supplementary motor/primary motor cortex. Two subnetworks that did not converge with nonhuman primates were connected to cortical regions associated with human language function. Thus, precision subnetworks identify detailed, individual-specific, neurobiologically plausible corticostriatal connectivity that includes human-specific language networks.

Indexed as

Corpus StriatumMotor CortexAnimalsBrain MappingFrontal LobeHumansMagnetic Resonance ImagingNeural PathwaysNucleus AccumbensPrefrontal CortexPutamenbrain networksfMRIfunctional connectivityindividual variabilitystriatum

Identifiers

PMID34718460
PMCPMC9247416
OpenAlexW3208532957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.