Evidence map›Paper›PMID 34718454›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2022

Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging.

Claire J Ciampa, Jourdan H Parent, Molly R Lapoint, Kaitlin N Swinnerton, Morgan M Taylor, Victoria R Tennant, A J Whitman, William J Jagust, Anne S Berry

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Alzheimer's Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Low Psychological Resilience Predict the Risk for Alcohol Use Disorder in General Population: National Mental Health Survey of Korea 2021.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Claire J CiampaDepartment of Psychology, Brandeis University, Waltham, MA 02453, USA.
Jourdan H ParentDepartment of Psychology, Brandeis University, Waltham, MA 02453, USA.
Molly R LapointHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Kaitlin N SwinnertonHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Morgan M TaylorDepartment of Psychology, Brandeis University, Waltham, MA 02453, USA.
Victoria R TennantHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
A J WhitmanMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
William J JagustHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Anne S BerryDepartment of Psychology, Brandeis University, Waltham, MA 02453, USA.
Brandeis University · USUniversity of California, Berkeley · USLawrence Berkeley National Laboratory · US

Funding

Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Mechanisms of Alzheimer's Disease Progression in the Aging BrainR01AG062542 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2019 to 2023
$4.2M
Aging Brain, Cognition, and DopamineR01AG044292 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI JAGUST, WILLIAM J. · 2013 to 2017
$3.6M
Predoctoral research training at the interface of brain, body, and behaviorT32GM132498 · NIGMS · BRANDEIS UNIVERSITY · PI PAUL DIZIO, ANGELA GUTCHESS · 2019 to 2026
$1.6M
Age effects on memory and reward systems in decision makingR00AG058748 · NIA · BRANDEIS UNIVERSITY · PI BERRY, ANNE SHIVELY · 2019 to 2021
$745k
Age effects on memory and reward systems in decision makingK99AG058748 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BERRY, ANNE SHIVELY · 2018 to 2019
$250k
NIA NIH HHS K99 AG058748NIA NIH HHS R00 AG058748NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG044292NIA NIH HHS R01 AG062542NIGMS NIH HHS T32 GM132498
6 · The paper itself

Abstract

Aging is associated with declines in multiple components of the dopamine system including loss of dopamine-producing neurons, atrophy of the dopamine system's cortical targets, and reductions in the density of dopamine receptors. Countering these patterns, dopamine synthesis appears to be stable or elevated in older age. We tested the hypothesis that elevation in dopamine synthesis in aging reflects a compensatory response to neuronal loss rather than a nonspecific monotonic shift in older age. We measured individual differences in striatal dopamine synthesis capacity in cognitively normal older adults using [18F]Fluoro-l-m-tyrosine positron emission tomography cross-sectionally and tested relationships with longitudinal reductions in cortical thickness and working memory decline beginning up to 13 years earlier. Consistent with a compensation account, older adults with the highest dopamine synthesis capacity were those with greatest atrophy in posterior parietal cortex. Elevated dopamine synthesis capacity was not associated with successful maintenance of working memory performance overall, but had a moderating effect such that higher levels of dopamine synthesis capacity reduced the impact of atrophy on cognitive decline. Together, these findings support a model by which upregulation of dopamine synthesis represents a mechanism of cognitive resilience in aging.

Indexed as

DopamineMagnetic Resonance ImagingAgedAgingAtrophyCognitionHumansPositron-Emission TomographyDopamineatrophycompensationolder adultsPETworking memory

Identifiers

PMID34718454
PMCPMC9247426
OpenAlexW3208188575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.