Evidence map›Paper›PMID 34718367›Full record

ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2022

Validation of the Taiwanese Version of ACE-III (T-ACE-III) to Detect Dementia in a Memory Clinic.

Ruan-Ching Yu, Naaheed Mukadam, Narinder Kapur, Joshua Stott, Chaur-Jong Hu, Chien-Tai Hong, Cheng-Chang Yang, Lung Chan, Li-Kai Huang, Gill Livingston

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ruan-Ching YuDepartment of Mental Health of Older People, University College London, London, UK.
Naaheed MukadamDepartment of Mental Health of Older People, University College London, London, UK.
Narinder KapurDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.
Joshua StottDepartment of Clinical, Educational and Health Psychology, University College London, London, UK.
Chaur-Jong HuDepartment of Neurology and Dementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Chien-Tai HongDepartment of Neurology and Dementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Cheng-Chang YangDepartment of Neurology and Dementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Lung ChanDepartment of Neurology and Dementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Li-Kai HuangDepartment of Neurology and Dementia Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Gill LivingstonDepartment of Mental Health of Older People, University College London, London, UK.
Taipei Medical University-Shuang Ho Hospital · TWUniversity College London · GBMental Health Research UK · GB

Funding

Ministry of EducationNational Institute for Health Research
6 · The paper itself

Abstract

objectiveThe Addenbrooke's Cognitive Examination III (ACE-III) is a 100-points cognitive test used in detecting dementia in many countries. There has been no validation study of the ACE-III in patients with suspected dementia in a Taiwanese population, where the language is traditional Chinese. We aimed to culturally adapt and validate the ACE-III as a cognitive assessment tool for differentiating between people with and without dementia presenting to healthcare professionals in Taiwan with possible dementia.

methodsWe culturally adapted the ACE-III for Taiwan (T-ACE-III) and tested it with consenting patients with suspected dementia in northern Taiwan who had been through the diagnostic process. We calculated receiver operating characteristic (ROC) curves to test the ability of the T-ACE-III to differentiate between dementia and non-dementia cases using clinician diagnosis as the gold standard. We generated the Youden Index to determine the best cut-off score.

resultsWe recruited 90 Taiwanese individuals aged 49-93 years: 24 males and 33 females had dementia and 12 males and 21 females did not. The area under the ROC curve was 0.99 for distinguishing dementia from non-dementia. The T-ACE-III had a sensitivity of 100% and specificity of 78.8% when the cut-off score was 86/87. With a cut-off value of 73/74, the specificity was 100.0%, and sensitivity 89.5%. The highest Youden Index was 0.895, indicating the best overall cut-off point to be 73/74.

conclusionsThe T-ACE-III is an acceptable cognitive test with excellent psychometric properties for discriminating dementia from non-dementia in Taiwanese populations in memory clinic settings.

Indexed as

Cognitive DysfunctionDementiaFemaleHumansLanguageMaleNeuropsychological TestsReproducibility of ResultsROC CurveCognitive assessmentCross-cultural/minorityDementia

Identifiers

PMID34718367
PMCPMC9035086
OpenAlexW3209043844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.