Evidence map›Paper›PMID 34718334›Full record

ArticleInternational journal of obesity (2005)2022

Third trimester cortisol is positively associated with gestational weight gain in pregnant women with class one obesity.

Christine H Naya, Claudia M Toledo-Corral, Thomas Chavez, Deborah Lerner, Nathana Lurvey, Sandrah P Eckel, Alicia K Peterson, Brendan H Grubbs, Genevieve F Dunton, Carrie V Breton and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christine H NayaDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1575-6308
Claudia M Toledo-CorralDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Thomas ChavezDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Deborah LernerEisner Health, Los Angeles, CA, USA.
Nathana LurveyEisner Health, Los Angeles, CA, USA.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alicia K PetersonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brendan H GrubbsDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Genevieve F DuntonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carrie V BretonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6082-4066
Theresa M BastainDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. bastain@usc.edu.ORCID http://orcid.org/0000-0002-0029-5641
University of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic LoadP50MD015705 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M · 2020 to 2024
$8.1M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M · 2015 to 2019
$3.7M
NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P50 ES026086NIH HHS UH3 OD023287NIMHD NIH HHS P50 MD015705
6 · The paper itself

Abstract

BACKGROUND/

objectivePrevalence of pre-pregnancy obesity and excessive gestational weight gain (GWG) are higher among women of color with low SES. Dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and its end-product, cortisol, during pregnancy is hypothesized to be associated with excessive GWG. However, past studies have produced inconsistent findings and often did not include health disparities populations. This study examined the association between pre-pregnancy body mass index (BMI), third trimester diurnal cortisol, and GWG in low-income, predominantly Hispanic women. SUBJECTS/

methodsThe MADRES study is an ongoing prospective cohort study of primarily Hispanic, low-income pregnant women and their children in Los Angeles, California. Data from 176 participants were included in this study. Total cortisol secretion (area under the curve, AUC) was quantified using four salivary cortisol samples (awakening, 30 min after awakening, afternoon, and bedtime) that were collected at home on one day during the third trimester of pregnancy. Moderation of the association between total cortisol and GWG by pre-pregnancy BMI was tested using multiple linear regression with a multiplicative interaction term.

resultsThere was no association between total cortisol secretion and GWG overall (p = 0.82), but the association between total cortisol and GWG was stronger for women with class 1 pre-pregnancy obesity compared to women with normal pre-pregnancy BMI (interaction term p = 0.04).

conclusionsResults suggest that obesity status before pregnancy may be exacerbating the physiological impact of cortisol on GWG.

Indexed as

AdultAnalysis of VarianceCohort StudiesFemaleGestational AgeGestational Weight GainHumansHydrocortisoneLos AngelesObesityPregnancyPregnancy Trimester, ThirdPregnant PeopleHydrocortisone

Identifiers

PMID34718334
PMCPMC9012147
OpenAlexW3209322438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.