Evidence map›Paper›PMID 34718225›Full record

ArticleMolecular pharmacology2022

Steroidal Antagonists of Progesterone- and Prostaglandin E

Erick J Carlson, Gunda I Georg, Jon E Hawkinson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Mating behaviors in ovoviviparous black rockfish (Marine life science & technology · 2024
    Article
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Erick J CarlsonDepartment of Medicinal Chemistry (E.J.C., G.I.G., J.E.H.) and Institute for Therapeutics Discovery and Development (G.I.G., J.E.H.), University of Minnesota, Minneapolis, Minnesota.
Gunda I GeorgDepartment of Medicinal Chemistry (E.J.C., G.I.G., J.E.H.) and Institute for Therapeutics Discovery and Development (G.I.G., J.E.H.), University of Minnesota, Minneapolis, Minnesota hawkinso@umn.edu georg@umn.edu.
Jon E HawkinsonDepartment of Medicinal Chemistry (E.J.C., G.I.G., J.E.H.) and Institute for Therapeutics Discovery and Development (G.I.G., J.E.H.), University of Minnesota, Minneapolis, Minnesota hawkinso@umn.edu georg@umn.edu.
University of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cation channel of sperm (CatSper) is the principal entry point for calcium in human spermatozoa and its proper function is essential for successful fertilization. As CatSper is potently activated by progesterone, we evaluated a range of steroids to define the structure-activity relationships for channel activation and found that CatSper is activated by a broad range of steroids with diverse structural modifications. By testing steroids that failed to elicit calcium influx as inhibitors of channel activation, we discovered that medroxyprogesterone acetate, levonorgestrel, and aldosterone inhibited calcium influx produced by progesterone, prostaglandin E

Indexed as

AldosteroneAlprostadilAzabicyclo CompoundsBenzamidesCalcium ChannelsDose-Response Relationship, DrugHumansLevonorgestrelMaleProgesteroneSemenSperm MotilitySteroidsStructure-Activity RelationshipAldosteroneAlprostadilAzabicyclo CompoundsBenzamidesCalcium ChannelsCATSPER1 protein, humanLevonorgestrelML218 compoundProgesteroneSteroids

Identifiers

PMID34718225
PMCPMC8969127
OpenAlexW3208071352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.