Evidence map›Paper›PMID 34718165›Full record

ReviewAutoimmunity reviews2021

The COVID-19 pandemic and ANCA-associated vasculitis - reports from the EUVAS meeting and EUVAS education forum.

Andreas Kronbichler, Duvuru Geetha, Rona M Smith, Allyson C Egan, Ingeborg M Bajema, Ulf Schönermarck, Alfred Mahr, Hans-Joachim Anders, Annette Bruchfeld, Maria C Cid and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Autoimmunity reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Top ten tips in managing ANCA vasculitis.Clinical kidney journal · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. ANCA-associated vasculitis-treatment standard.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. COVID-19 and Glomerular Diseases.Kidney international reports · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 7 countries.

Andreas KronbichlerDepartment of Medicine, University of Cambridge, CB2 0QQ Cambridge, United Kingdom. Electronic address: ak2283@cam.ac.uk.
Duvuru GeethaDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rona M SmithDepartment of Medicine, University of Cambridge, CB2 0QQ Cambridge, United Kingdom.
Allyson C EganDepartment of Medicine, University of Cambridge, CB2 0QQ Cambridge, United Kingdom.
Ingeborg M BajemaDepartment of Pathology, L1Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.
Ulf SchönermarckDivision of Nephrology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany.
Alfred MahrDepartment of Rheumatology, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
Hans-Joachim AndersDivision of Nephrology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany.
Annette BruchfeldDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institutet, Stockholm, Sweden.
Maria C CidDepartment of Autoimmune Diseases, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
David R W JayneDepartment of Medicine, University of Cambridge, CB2 0QQ Cambridge, United Kingdom.
University of Cambridge · GBLMU Klinikum · DEConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESJohns Hopkins University · USKantonsspital St. Gallen · CHLeiden University Medical Center · NLLinköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Coronavirus Disease 2019 (COVID-19) pandemic influenced the management of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. A paucity of data exists on outcome of patients with vasculitis following COVID-19, but mortality is higher than in the general population and comparable to patients undergoing haemodialysis or kidney transplant recipients (reported mortality rates of 20-25%). Delays in diagnosis have been reported, which are associated with sequelae such as dialysis-dependency. Management of ANCA-associated vasculitis has not changed with the aim to suppress disease activity and reduce burden of disease. The use of rituximab, an important and widely used agent, is associated with a more severe hospital course of COVID-19 and absence of antibodies following severe acute respiratory syndrome (SARS)-CoV-2 infections, which prone patients to re-infection. Reports on vaccine antibody response are scarce at the moment, but preliminary findings point towards an impaired immune response, especially when patients receive rituximab as part of their treatment. Seropositivity was reported in less than 20% of patients when rituximab was administered within the prior six months, and the antibody response correlated with CD19

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCOVID-19Antibodies, Antineutrophil CytoplasmicCOVID-19 VaccinesHumansPandemicsRituximabSARS-CoV-2Antibodies, Antineutrophil CytoplasmicCOVID-19 VaccinesRituximab

Identifiers

PMID34718165
PMCPMC8552556
OpenAlexW3209939069

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.