Evidence map›Paper›PMID 34717702›Full record

ArticleJournal of orthopaedic surgery and research2021

Protective effects of low-magnitude high-frequency vibration on high glucose-induced osteoblast dysfunction and bone loss in diabetic rats.

Zhaoyu Fu, Xu Huang, Pengcheng Zhou, Bo Wu, Long Cheng, Xinyu Wang, Dong Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhaoyu FuDepartment of Orthopaedic Trauma, The First Hospital of Jilin University, Changchun, Jilin, China.
Xu HuangDepartment of Radiology, The First Hospital of Jilin University, Changchun, Jilin, China.
Pengcheng ZhouDepartment of Orthopaedic Trauma, The First Hospital of Jilin University, Changchun, Jilin, China.
Bo WuDepartment of Orthopaedic Trauma, The First Hospital of Jilin University, Changchun, Jilin, China.
Long ChengDepartment of Orthopaedic Trauma, The First Hospital of Jilin University, Changchun, Jilin, China.
Xinyu WangDepartment of Orthopaedic Trauma, The First Hospital of Jilin University, Changchun, Jilin, China.
Dong ZhuDepartment of Orthopaedic Trauma, The First Hospital of Jilin University, Changchun, Jilin, China. zhu_dong@mail.jlu.edu.cn.ORCID http://orcid.org/0000-0001-9422-2103
Jilin University · CN

Funding

National Natural Science Foundation of China 12072129
6 · The paper itself

Abstract

objectiveLow-magnitude high-frequency vibration (LMHFV) has been reported to be capable of promoting osteoblast proliferation and differentiation. Reduced osteoblast activity and impaired bone formation were related to diabetic bone loss. We investigated the potential protective effects of LMHFV on high-glucose (HG)-induced osteoblasts in this study. In addition, the assessment of LMHFV treatment for bone loss attributed to diabetes was also performed in vivo.

methodMC3T3-E1 cells induced by HG only or treated with LMHFV were treated in vitro. The experiments performed in this study included the detection of cell proliferation, migration and differentiation, as well as protein expression. Diabetic bone loss induced by streptozotocin (STZ) in rats was established. Combined with bone morphometric, microstructure, biomechanical properties and matrix composition tests, the potential of LMHFV in treating diabetes bone loss was explored.

resultsAfter the application of LMHFV, the inhibiting effects of HG on the proliferation, migration and differentiation of osteoblasts were alleviated. The GSK3β/β-catenin pathway was involved in the protective effect of LMHFV. Impaired microstructure and biomechanical properties attributed to diabetes were ameliorated by LMHFV treatment. The improvement of femur biomechanical properties might be associated with the alteration of the matrix composition by the LMHFV.

conclusionLMHFV exhibited a protective effect on osteoblasts against HG by regulating the proliferation, migration and differentiation of osteoblasts. The function of promoting bone formation and reinforcing bone strength made it possible for LMHFV to alleviate diabetic bone loss.

Indexed as

Bone Diseases, MetabolicDiabetes Mellitus, ExperimentalAnimalsCell DifferentiationGlucoseOsteoblastsOsteogenesisRatsVibrationGlucoseBone lossDiabetic ratHigh glucoseLow-magnitude high-frequency vibrationOsteoblast

Identifiers

PMID34717702
PMCPMC8557505
OpenAlexW3208471714

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.