ArticleRadiation oncology (London, England)2021
Long-term cancer survivors treated with multiple courses of repeat radiation therapy.
Article in Radiation oncology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Modeling Time-Dependent Recovery to Improve Esophagitis Prediction in Thoracic Reirradiation.International journal of radiation oncology, biology, physics · 2026Article
- Comparative evaluation of dose accumulation strategies in the clinical reirradiation setting.Physics and imaging in radiation oncology · 2026Article
- A Precise Reirradiation Supporting Tool Initiative (PRISTIN) for Prescribing Absorbed Dose and Number of Fractions in Reirradiation.Advances in radiation oncology · 2025Article
- Clinical workflow for reirradiation: national consensus recommendations on imaging, treatment planning, dose accumulation, and treatment delivery.Acta oncologica (Stockholm, Sweden) · 2025Article
- A comprehensive national audit of radiotherapy retreatment numbers, sites and indications.Acta oncologica (Stockholm, Sweden) · 2025Article
- Efficacy and safety analysis in metastatic cancer patients treated with multiple courses of repeat radiation therapy.Clinical and translational radiation oncology · 2023Article
- Dosimetric analysis of 17 cardiac Sub-structures, Toxicity, and survival in ultra central lung tumor patients treated with SBRT.Clinical and translational radiation oncology · 2023Article
- The pattern of failure after Stereotactic Radiation Therapy (SRT) for oligo-metastases: predictive factors for poly-progression.Journal of cancer research and clinical oncology · 2023Article
- Quality-of-life and toxicity in cancer patients treated with multiple courses of radiation therapy.Clinical and translational radiation oncology · 2022Article
- RAdiotherapy Dose Accumulation Routine (RADAR)-A Novel Dose Accumulation Script With Built-In Uncertainty.Practical radiation oncologyArticle
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Authors and funding
7 authors.
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Abstract
INTRODUCTION AND
backgroundThrough recent advances in cancer care, the number of long-term survivors has continuously increased. As a result, repetitive use of local radiotherapy for curative or palliative indications might have increased as well. This analysis aims to describe patterns of care and outcome of patients treated with multiple courses of repeat radiotherapy. MATERIALS AND
methodsAll patients treated with radiotherapy between 2011 and 2019 at our department of Radiation Oncology were included into this analysis. A course of radiotherapy was defined as all treatment sessions to one anatomical site under one medical indication. Demographics, cancer and treatment characteristics and overall survival of patients having undergone multiple radiotherapy courses (minimum n = 5) were evaluated.
resultsThe proportion of cancer patients treated with a minimum five courses of radiotherapy increased continuously from 0.9% in 2011 to 6.5% in 2019. In the 112 patients treated with a minimum of five radiotherapy courses, the primary tumor was lung in 41.9% (n = 47), malignant melanoma in 8.9% (n = 10) and breast in 8.0% (n = 9) of cases. A median interval of 3 years (maximum 8 years) elapsed between the first and the last radiotherapy course. The maximum number of courses in a single patient were n = 10. Treatment intent was curative or palliative in 46.4% and 53.6% for the first radiotherapy, respectively. The proportion of curative intent decreased to 11.6% at the 5th, and the last radiotherapy course was following a palliative intent in all patients. Five-year overall survival measured from the 1st radiotherapy course was 32.7%. Median overall survival was 3.3, 2.4, 1.3, and 0.6 years when measured from the 1st, the 1st palliative, the 5th and last course of radiotherapy, respectively. DISCUSSION AND
conclusionA continuously increasing number of patients is treated with multiple courses of radiotherapy throughout their long-term cancer survivorship.
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