Evidence map›Paper›PMID 34717658›Full record

ReviewJournal of nanobiotechnology2021

Nanomedicine for increasing the oral bioavailability of cancer treatments.

Alessandro Parodi, Polina Buzaeva, Daria Nigovora, Alexey Baldin, Dmitry Kostyushev, Vladimir Chulanov, Lyudmila V Savvateeva, Andrey A Zamyatnin

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandro ParodiInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia. aparodi.sechenovuniversity@gmail.com.
Polina BuzaevaInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
Daria NigovoraInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
Alexey BaldinBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia.
Dmitry KostyushevSirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia.
Vladimir ChulanovSirius University of Science and Technology, 1 Olympic Ave, 354340, Sochi, Russia.
Lyudmila V SavvateevaInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
Andrey A ZamyatninInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia. zamyat@belozersky.msu.ru.

Funding

Russian Science Foundation (grant # 21-75-30020)
6 · The paper itself

Abstract

Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines.

Indexed as

NanomedicineAdministration, OralAnimalsAntineoplastic AgentsBiological AvailabilityDrug Delivery SystemsHumansNeoplasmsPharmaceutical PreparationsAntineoplastic AgentsPharmaceutical PreparationsBiological barriersCancer treatmentOral nanomedicine

Identifiers

PMID34717658
PMCPMC8557561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.