Evidence map›Paper›PMID 34717545›Full record

ArticleBMC genomics2021

Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury.

Adam Doelman, Seth Tigchelaar, Brian McConeghy, Sunita Sinha, Martin S Keung, Neda Manouchehri, Megan Webster, Shera Fisk, Charlotte Morrison, Femke Streijger and 2 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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  9. The Role of the Gut Microbiome in Orthopedic Surgery-a Narrative Review.Current reviews in musculoskeletal medicine · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Adam DoelmanInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Seth TigchelaarInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Brian McConeghySequencing and Bioinformatics Consortium, University of British Columbia, Vancouver, BC, Canada.
Sunita SinhaSequencing and Bioinformatics Consortium, University of British Columbia, Vancouver, BC, Canada.
Martin S KeungInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Neda ManouchehriInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Megan WebsterInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Shera FiskInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Charlotte MorrisonInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Femke StreijgerInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Corey NislowSequencing and Bioinformatics Consortium, University of British Columbia, Vancouver, BC, Canada.
Brian K KwonInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada. brian.kwon@ubc.ca.
University of British Columbia · CAInternational Collaboration On Repair Discoveries · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gut microbiome is a diverse network of bacteria which inhabit our digestive tract and is crucial for efficient cellular metabolism, nutrient absorption, and immune system development. Spinal cord injury (SCI) disrupts autonomic function below the level of injury and can alter the composition of the gut microbiome. Studies in rodent models have shown that SCI-induced bacterial imbalances in the gut can exacerbate the spinal cord damage and impair recovery. In this study we, for the first time, characterized the composition of the gut microbiome in a Yucatan minipig SCI model. We compared the relative abundance of the most dominant bacterial phyla in control samples to those collected from animals who underwent a contusion-compression SCI at the 2nd or 10th Thoracic level.

resultsWe identify specific bacterial fluctuations that are unique to SCI animals, which were not found in uninjured animals given the same dietary regimen or antibiotic administration. Further, we identified a specific time-frame, "SCI-acute stage", during which many of these bacterial fluctuations occur before returning to "baseline" levels.

conclusionThis work presents a dynamic view of the microbiome changes that accompany SCI, establishes a resource for future studies and to understand the changes that occur to gut microbiota after spinal cord injury and may point to a potential therapeutic target for future treatment.

Indexed as

Gastrointestinal MicrobiomeSpinal Cord InjuriesAnimalsBacteriaSpinal CordSwineSwine, MiniatureAntibioticDietGut-brain AxisMicrobiomePigSpinal Cord Injury

Identifiers

PMID34717545
PMCPMC8557039
OpenAlexW3208732913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.