Evidence map›Paper›PMID 34717541›Full record

ArticleBMC emergency medicine2021

Amino acids predict prognosis in patients with acute dyspnea.

Karolin Wiklund, Klas Gränsbo, Peter Almgren, Marjaneh Peyman, Lena Tegnér, Maria Toni-Bengtsson, Mattias Wieloch, Olle Melander

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Karolin WiklundThe Department of Clinical Sciences Malmo, Faculty of Medicine, Lund University, Malmo, Sweden. karolin.wiklund@med.lu.se.ORCID 0000-0002-3807-5978
Klas GränsboThe Department of Clinical Sciences Malmo, Faculty of Medicine, Lund University, Malmo, Sweden.
Peter AlmgrenThe Department of Clinical Sciences Malmo, Faculty of Medicine, Lund University, Malmo, Sweden.
Marjaneh PeymanThe Department of Internal Medicine and Emergency Medicine, Skane University Hospital, Malmo, Sweden.
Lena TegnérThe Department of Internal Medicine and Emergency Medicine, Skane University Hospital, Malmo, Sweden.
Maria Toni-BengtssonThe Department of Internal Medicine and Emergency Medicine, Skane University Hospital, Malmo, Sweden.
Mattias WielochThe Department of Clinical Sciences Malmo, Faculty of Medicine, Lund University, Malmo, Sweden.
Olle MelanderThe Department of Clinical Sciences Malmo, Faculty of Medicine, Lund University, Malmo, Sweden.
Lund University · SESkåne University Hospital · SEMalmö University · SE

Funding

European Research Council 885003
6 · The paper itself

Abstract

backgroundTo identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea.

methodPlasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality.

resultEighty patients (12.1%) died within 90 days of admission. An "Amino Acid Mortality Risk Score" (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of 1 SD in the AMRS was associated with a hazard ratio (HR) of 2.15 for 90-day mortality, and the HR was > 9 times higher in Q4.

conclusionGlycine, phenylalanine and valine are associated with a risk of 90-day mortality in patients admitted to the ED for acute dyspnea, suggesting that these amino acids may be useful in risk assessments.

Indexed as

Amino AcidsDyspneaAdultBiomarkersEmergency Service, HospitalHumansPrognosisAmino AcidsBiomarkersAmino acidsDyspneaEmergency service, hospitalGlycinePhenylalanineValine

Identifiers

PMID34717541
PMCPMC8557597
OpenAlexW3209855934

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.