ArticlePlant biotechnology journal2022
Genome and systems biology of Melilotus albus provides insights into coumarins biosynthesis.
Article in Plant biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Sarcandra glabra genome unveils functional conservation and divergence of O-methyltransferases catalyzing isofraxidin biosynthesis in angiosperms.Nature communications · 2026Article
- Identification of candidate genes governing key metabolic pathways in fenugreek (Trigonella spp.) through integrated transcriptomic and metabolomic analysis.Functional & integrative genomics · 2026Article
- Growth Year and Chemotype Synergistically Regulate Coumarin Accumulation and the Associated Transcriptional Profiles inPlants (Basel, Switzerland) · 2026Article
- A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in Artemisia capillaris.Plant biotechnology journal · 2026Article
- Combining metabolomics and transcriptomics to reveal the effect of β-glucosidase on scopolin in Angelica dahurica var. formosana.BMC plant biology · 2025Article
- Forage Crop Research in the Modern Age.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The biosynthetic pathway of coumarin and its genetic regulation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- The Mitochondrial Blueprint: Unlocking Secondary Metabolite Production.Metabolites · 2024Review
- Comparative Transcriptome Analysis Revealing the Potential Salt Tolerance Mechanism of Exogenous Abscisic Acid Application inInternational journal of molecular sciences · 2024Article
- Multi-omics analysis reveals genetic architecture and local adaptation of coumarins metabolites in Populus.BMC plant biology · 2024Article
- Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- A comparative plastome approach enhances the assessment of genetic variation in the Melilotus genus.BMC genomics · 2024Article
- Genome assembly of Melilotus officinalis provides a new reference genome for functional genomics.BMC genomic data · 2024Article
- Article
- Integration of transcriptome and metabolome analyses reveals the role of OsSPL10 in rice defense against brown planthopper.Plant cell reports · 2023Article
- Genome-Wide Identification of the Trihelix Transcription Factor Family and Functional Analysis of the Drought Stress-Responsive Genes inPlants (Basel, Switzerland) · 2023Article
- Chromosome-scale assembly and analysis of Melilotus officinalis genome for SSR development and nodulation genes analysis.The plant genome · 2023Article
- Identification of a Novel Coumarins Biosynthetic Pathway in the Endophytic Fungus Fusarium oxysporum GU-7 with Antioxidant Activity.Applied and environmental microbiology · 2023Article
- Review
- Genome-Wide Analysis of theInternational journal of molecular sciences · 2022Article
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Authors and funding
18 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melilotus species are used as green manure and rotation crops worldwide and contain abundant pharmacologically active coumarins. However, there is a paucity of information on its genome and coumarin production and function. Here, we reported a chromosome-scale assembly of Melilotus albus genome with 1.04 Gb in eight chromosomes, containing 71.42% repetitive elements. Long terminal repeat retrotransposon bursts coincided with declining of population sizes during the Quaternary glaciation. Resequencing of 94 accessions enabled insights into genetic diversity, population structure, and introgression. Melilotus officinalis had relatively larger genetic diversity than that of M. albus. The introgression existed between M. officinalis group and M. albus group, and gene flows was from M. albus to M. officinalis. Selection sweep analysis identified candidate genes associated with flower colour and coumarin biosynthesis. Combining genomics, BSA, transcriptomics, metabolomics, and biochemistry, we identified a β-glucosidase (BGLU) gene cluster contributing to coumarin biosynthesis. MaBGLU1 function was verified by overexpression in M. albus, heterologous expression in Escherichia coli, and substrate feeding, revealing its role in scopoletin (coumarin derivative) production and showing that nonsynonymous variation drives BGLU enzyme activity divergence in Melilotus. Our work will accelerate the understanding of biologically active coumarins and their biosynthetic pathways, and contribute to genomics-enabled Melilotus breeding.
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