Evidence map›Paper›PMID 34717196›Full record

ArticleBiomaterials2021

Development of a magnetically aligned regenerative tissue-engineered electronic nerve interface for peripheral nerve applications.

Mary Kasper, Bret Ellenbogen, Ryan Hardy, Madison Cydis, Jorge Mojica-Santiago, Abdullah Afridi, Benjamin S Spearman, Ishita Singh, Cary A Kuliasha, Eric Atkinson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Design, Fabrication, and Implantation of Hollow Tissue-Engineered Electronic Nerve Interfaces.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Examining theJournal of neural engineering · 2022
    Article
  17. Review
  18. Review
  19. Review
  20. TiFrontiers in bioengineering and biotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mary KasperJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville, FL, 32611, USA.
Bret EllenbogenDepartment of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611, USA.
Ryan HardyDepartment of Materials Science and Engineering, University of Florida, 549 Gale Lemerand Dr., P.O. Box 116400, Gainesville, FL, 32611, USA.
Madison CydisJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville, FL, 32611, USA.
Jorge Mojica-SantiagoJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville, FL, 32611, USA.
Abdullah AfridiDepartment of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611, USA.
Benjamin S SpearmanJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville, FL, 32611, USA.
Ishita SinghDepartment of Chemical Engineering, University of Florida, 1030 Center Dr., P.O. Box 116005, Gainesville, FL, 32611, USA.
Cary A KuliashaDepartment of Electrical and Computer Engineering, University of Florida, 968 Center Dr., Gainesville, FL, 32611, USA.
Eric AtkinsonDepartment of Neuroscience, 1149 Newell Dr. L1-100, P.O. Box 100244, University of Florida, Gainesville, FL, 32610, USA.
Kevin J OttoJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville, FL, 32611, USA; Department of Materials Science and Engineering, University of Florida, 549 Gale Lemerand Dr., P.O. Box 116400, Gainesville, FL, 32611, USA; Department of Electrical and Computer Engineering, University of Florida, 968 Center Dr., Gainesville, FL, 32611, USA; Department of Neuroscience, 1149 Newell Dr. L1-100, P.O. Box 100244, University of Florida, Gainesville, FL, 32610, USA; Department of Neurology, 1149 Newell Dr. L3-100, P.O. Box 100236, University of Florida, Gainesville, FL, 32610, USA.
Jack W JudyDepartment of Electrical and Computer Engineering, University of Florida, 968 Center Dr., Gainesville, FL, 32611, USA.
Carlos Rinaldi-RamosJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville, FL, 32611, USA; Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611, USA.
Christine E SchmidtJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. JG56, P.O. Box 116131, Gainesville, FL, 32611, USA. Electronic address: schmidt@bme.ufl.edu.

Funding

The Tissue-Engineered Electronic Nerve Interface (TEENI)R01NS111518 · NINDS · UNIVERSITY OF FLORIDA · PI JUDY, JACK W · 2019 to 2022
$2.4M
Magnetically Templated Regeneration Scaffolds for Nerve Injury RepairR21NS093239 · NINDS · UNIVERSITY OF FLORIDA · PI RINALDI-RAMOS, CARLOS M, SCHMIDT, CHRISTINE E · 2015 to 2016
$401k
NINDS NIH HHS R01 NS111518NINDS NIH HHS R21 NS093239
6 · The paper itself

Abstract

Peripheral nerve injuries can be debilitating to motor and sensory function, with severe cases often resulting in complete limb amputation. Over the past two decades, prosthetic limb technology has rapidly advanced to provide users with crude motor control of up to 20° of freedom; however, the nerve-interfacing technology required to provide high movement selectivity has not progressed at the same rate. The work presented here focuses on the development of a magnetically aligned regenerative tissue-engineered electronic nerve interface (MARTEENI) that combines polyimide "threads" encapsulated within a magnetically aligned hydrogel scaffold. The technology exploits tissue-engineered strategies to address concerns over traditional peripheral nerve interfaces including poor axonal sampling through the nerve and rigid substrates. A magnetically templated hydrogel is used to physically support the polyimide threads while also promoting regeneration in close proximity to the electrode sites on the polyimide. This work demonstrates the utility of magnetic templating for use in tuning the mechanical properties of hydrogel scaffolds to match the stiffness of native nerve tissue while providing an aligned substrate for Schwann cell migration in vitro. MARTEENI devices were fabricated and implanted within a 5-mm-long rat sciatic-nerve transection model to assess regeneration at 6 and 12 weeks. MARTEENI devices do not disrupt tissue remodeling and show axon densities equivalent to fresh tissue controls around the polyimide substrates. Devices are observed to have attenuated foreign-body responses around the polyimide threads. It is expected that future studies with functional MARTEENI devices will be able to record and stimulate single axons with high selectivity and low stimulation regimes.

Indexed as

Nerve RegenerationNerve TissueAnimalsAxonsElectronicsRatsSchwann CellsSciatic NerveTissue Engineering

Identifiers

PMID34717196
PMCPMC9036633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.