ArticleUltrasonics2022
Acoustic properties across the human skull.
Article in Ultrasonics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcranial ultrasound stimulation parameters for neurological diseases: a systematic review.Frontiers in neurology · 2025Pooled it
- Noninvasive Modulation of the Subcallosal Cingulate and Depression With Focused Ultrasonic Waves.Biological psychiatry · 2025Trial
- Backward sensing FUS modulated light from a brain phantom through human adult skull specimen.Biomedical optics express · 2026Article
- Focused Ultrasound Modulation of PGC-1α Pathways in Neurological Disease: Mechanistic Rationale and Translational Opportunities.Molecular neurobiology · 2026Review
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- Acoustic Detection of Intracranial Cavitation Induced by Blunt Impacts in Polyacrylamide Human Head Models Across Varying Orientations.Annals of biomedical engineering · 2026Article
- Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Ocular vestibular-evoked myogenic potentials in unilateral Ménière's disease: a narrative literature review.Frontiers in neurology · 2026Review
- Clearance of amyloid plaque via focused ultrasonication in a mouse model of Alzheimer's disease.Theranostics · 2026Article
- Thermo-Magnetic Induction of Pro-Inflammatory Microglia: A Lipid-Based Nanovector Strategy for Glioblastoma Immunotherapy.ACS applied materials & interfaces · 2025Article
- The mouse motor cortex stimulation via non-invasive temporal interference transcranial focused ultrasound with microbubbles.Ultrasonics sonochemistry · 2025Article
- Transcranial ultrasound tomography for brain imaging: Ex vivo results and potential for stroke imaging.Medical physics · 2025Article
- Brain modes of resonance estimated by a biophysical multi-compartment finite elements model.Scientific reports · 2025Article
- Optimization of MR acoustic radiation force imaging (MR-ARFI) for human transcranial focused ultrasound.Magnetic resonance in medicine · 2025Article
- Quantification of the relative contribution of phase aberration and reverberation in transcranial ultrasound imaging: an experimentally calibrated fullwave study in 2D and 3D.Physics in medicine and biology · 2025Article
- Volumetric Passive Acoustic Mapping and Cavitation Detection of Nanobubbles under Low-Frequency Insonation.ACS materials Au · 2025Article
- Experimental Investigation of Focused Ultrasound Transmission through Rat Skulls.Advanced devices & instrumentation · 2025Article
- A Deep Learning-Based Approach to Characterize Skull Physical Properties: A Phantom Study.Journal of biophotonics · 2025Article
- A Physiological Marker for Deep Brain Ultrasonic Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Treatment envelope of transcranial histotripsy: challenges and strategies to maximize the treatment location profile.Physics in medicine and biology · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Transcranial ultrasound is emerging as a noninvasive tool for targeted treatments of brain disorders. Transcranial ultrasound has been used for remotely mediated surgeries, transient opening of the blood-brain barrier, local drug delivery, and neuromodulation. However, all applications have been limited by the severe attenuation and phase distortion of ultrasound by the skull. Here, we characterized the dependence of the aberrations on specific anatomical segments of the skull. In particular, we measured ultrasound propagation properties throughout the perimeter of intact human skulls at 500 kHz. We found that the parietal bone provides substantially higher transmission (average pressure transmission 31 ± 7%) and smaller phase distortion (242 ± 44 degrees) than frontal (13 ± 2%, 425 ± 47 degrees) and occipital bone regions (16 ± 4%, 416 ± 35 degrees). In addition, we found that across skull regions, transmission strongly anti-correlated (R=-0.79) and phase distortion correlated (R=0.85) with skull thickness. This information guides the design, positioning, and skull correction functionality of next-generation devices for effective, safe, and reproducible transcranial focused ultrasound therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.