ArticleAllergy2022
Development and validation of the food allergy severity score.
Article in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Taste aversion and adverse events contribute equally to OIT discontinuation in children: A real-world multi-allergen analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Observational
- Allergenicity of Eight Soy Products: Allergy to Soy Milk Is Most Frequent and Most Severe.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Safety and efficiency of peanut oral immunotherapy in preschool children with slow up-dosing and low maintenance dosing: a randomised controlled trial.The Lancet regional health. Europe · 2026Article
- Predicting outcomes of hazelnut oral food challenge: Pediatric cohort analysis.The journal of allergy and clinical immunology. Global · 2026Article
- Frequency and severity of 192 foods causing food allergy in adults.The journal of allergy and clinical immunology. Global · 2026Article
- Birch Pollen-Related Food Allergy: Occasionally Severe, Yet Home-Based Oral Food Challenges Are Safe.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Quality-of-life assessment may support the correct diagnosis of adult wheat allergy.Allergologie select · 2026Article
- Diagnosing IgE-mediated food allergy: How to apply the latest guidelines in clinical practice.The journal of allergy and clinical immunology. Global · 2025Article
- Article
- Characterising Lipid Transfer Protein Allergy in UK Adults.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Orange Allergy Beyond LTP: IgE Recognition of Germin-like Proteins in Citrus Fruits.Current issues in molecular biology · 2025Article
- Anaphylaxis severity grade, during oral food challenges, assessed by five different classifications.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Observational
- Can cashew nut allergy resolve spontaneously?Clinical and translational allergy · 2024Article
- Behavior and Parenting Stress Characteristics in Young Children With Severe Food Allergies According to the Severity Score System.Allergy, asthma & immunology research · 2024Article
- Feast for thought: A comprehensive review of food allergy 2021-2023.The Journal of allergy and clinical immunology · 2024Review
- Group 2 innate lymphoid cells are key in lipid transfer protein allergy pathogenesis.Frontiers in immunology · 2024Article
- Clinical and sensitization profile in peach allergy due to LTP sensitization.Frontiers in allergy · 2024Article
- Protocol Development of a Personalized Balanced Nutrition Concept for Preschool Children, Primarily Those with Food Allergies, Using an IT Platform.Medicina (Kaunas, Lithuania) · 2023Article
- WAO consensus on DEfinition of Food Allergy SEverity (DEFASE).The World Allergy Organization journal · 2023Article
- Management of IgE-mediated food allergy in the 21st century.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2023Review
Corrections and comments
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Authors and funding
38 authors at 20 institutions in 19 countries.
Funding
Abstract
backgroundThe heterogeneity and lack of validation of existing severity scores for food allergic reactions limit standardization of case management and research advances. We aimed to develop and validate a severity score for food allergic reactions.
methodsFollowing a multidisciplinary experts consensus, it was decided to develop a food allergy severity score (FASS) with ordinal (oFASS) and numerical (nFASS) formats. oFASS with 3 and 5 grades were generated through expert consensus, and nFASS by mathematical modeling. Evaluation was performed in the EuroPrevall outpatient clinic cohort (8232 food reactions) by logistic regression with request of emergency care and medications used as outcomes. Discrimination, classification, and calibration were calculated. Bootstrapping internal validation was followed by external validation (logistic regression) in 5 cohorts (3622 food reactions). Correlation of nFASS with the severity classification done by expert allergy clinicians by Best-Worst Scaling of 32 food reactions was calculated.
resultsoFASS and nFASS map consistently, with nFASS having greater granularity. With the outcomes emergency care, adrenaline and critical medical treatment, oFASS and nFASS had a good discrimination (receiver operating characteristic area under the curve [ROC-AUC]>0.80), classification (sensitivity 0.87-0.92, specificity 0.73-0.78), and calibration. Bootstrapping over ROC-AUC showed negligible biases (1.0 × 10
conclusionFASS is a validated and reliable method to measure severity of food allergic reactions. The ordinal and numerical versions that map onto each other are suitable for use by different stakeholders in different settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.