Evidence map›Paper›PMID 34716921›Full record

ArticleAmerican journal of hematology2022

Prediction of early (4-week) mortality in acute myeloid leukemia with intensive chemotherapy.

Koji Sasaki, Tapan Kadia, Kebede Begna, Courtney D DiNardo, Gautam Borthakur, Nicholas J Short, Nitin Jain, Naval Daver, Elias Jabbour, Guillermo Garcia-Manero and 7 more

Abstract read
In one paragraph

Article in American journal of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  15. AML in the Elderly - When less may be more.Current oncology reports · 2024
    Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Koji SasakiDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-9140-0610
Tapan KadiaDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-9892-9832
Kebede BegnaDepartment of Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-2730-8593
Courtney D DiNardoDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-9003-0390
Gautam BorthakurDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-7679-6453
Nicholas J ShortDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-2983-2738
Nitin JainDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.
Naval DaverDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0001-7103-373X
Elias JabbourDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-4465-6119
Guillermo Garcia-ManeroDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-3631-2482
Guillermo Montalban BravoDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-4533-5176
Lucia MasarovaDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.
Sherry PierceDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.
Marina KonoplevaDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-9347-2212
Farhad RavandiDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-7621-377X
Ayalew TefferiDepartment of Medicine, Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-4605-3821
Hagop KantarjianDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
University of Texas M.D. Anderson Cancer SPORE-LeukemiaP50CA100632 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SHPALL, ELIZABETH J · 2003 to 2023
$43.7M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA100632
6 · The paper itself

Abstract

The progress with intensive chemotherapy and supportive care measures has improved survival in patients with newly diagnosed acute myeloid leukemia (AML). Given the recent development of effective low intensity therapies, an optimal decision on the therapy intensity may improve survival through the avoidance of early mortality. We reviewed the outcome of 3728 patients with newly diagnosed AML who received intensive chemotherapy between August 1980 and May 2020. Intensive chemotherapy was defined as a cumulative cytarabine dose ≥ 700 mg/m

Indexed as

AdultAgedAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMultivariate AnalysisPrognosisRetrospective Studies

Identifiers

PMID34716921
PMCPMC11809073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.