Evidence map›Paper›PMID 34716912›Full record

ArticleAging clinical and experimental research2022

Associations of pre-pandemic levels of physical function and physical activity with COVID-19-like symptoms during the outbreak.

Marguerita Saadeh, Amaia Calderón-Larrañaga, Davide Liborio Vetrano, Philip von Rosen, Laura Fratiglioni, Anna-Karin Welmer

Open access · hybridAbstract read
In one paragraph

Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Marguerita SaadehAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet & Stockholm University, Solna, Sweden. marguerita.saadeh@ki.se.ORCID http://orcid.org/0000-0002-2689-5784
Amaia Calderón-LarrañagaAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet & Stockholm University, Solna, Sweden.
Davide Liborio VetranoAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet & Stockholm University, Solna, Sweden.
Philip von RosenDivision of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Laura FratiglioniAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet & Stockholm University, Solna, Sweden.
Anna-Karin WelmerAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet & Stockholm University, Solna, Sweden.
Stockholm University · SEKarolinska Institutet · SEKarolinska University Hospital · SE

Funding

Forskningsrådet för Arbetsliv och Socialvetenskap (2016-07175)Forskningsrådet om Hälsa, Arbetsliv och Välfärd (2016-07175)Vetenskapsrådet (SE) (2017-06088)Vetenskapsrådet (SE) (2020-05931)
6 · The paper itself

Abstract

backgroundOne's physical function and physical activity levels can predispose or protect from the development of respiratory infections. We aimed to explore the associations between pre-pandemic levels of physical function and physical activity and the development of COVID-19-like symptoms in Swedish older adults.

methodsWe analyzed data from 904 individuals aged ≥ 68 years from the population-based Swedish National study on Aging and Care in Kungsholmen. COVID-19-like symptoms were assessed by phone interview (March-June 2020) and included fever, cough, sore throat and/or a cold, headache, pain in muscles, legs and joints, loss of taste and/or odor, breathing difficulties, chest pain, gastrointestinal symptoms, and eye inflammation. Muscle strength, mobility, and physical activity were examined in 2016-2018 by objective testing. Data were analyzed using logistic regression models in the total sample and stratifying by age.

resultsDuring the first outbreak of the pandemic, 325 (36%) individuals from our sample developed COVID-19-like symptoms. Those with slower performance in the chair stand test had an odds ratio (OR) of 1.5 (95% confidence interval [CI] 1.1-2.1) for presenting with COVID-19-like symptoms compared to better performers, after adjusting for potential confounders. The association was even higher among people aged ≥ 80 years (OR 2.6; 95% CI 1.5-4.7). No significant associations were found between walking speed or engagement in moderate-to-vigorous physical activity and the likelihood to develop COVID-19-like symptoms.

conclusionPoor muscle strength, a possible indicator of frailty, may predispose older adults to higher odds of developing COVID-19-like symptoms, especially among the oldest-old.

Indexed as

COVID-19PandemicsAgedAged, 80 and overDisease OutbreaksExerciseHumansSARS-CoV-2Coronavirus disease 2019MobilityMuscle strengthOlder adultsPhysical activity

Identifiers

PMID34716912
PMCPMC8556821
OpenAlexW3209650927

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.