Evidence map›Paper›PMID 34716886›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2021

Mentha longifolia Alleviates Exogenous Serotonin-Induced Diabetic Hypoglycemia and Relieves Renal Toxicity via ROS Regulation.

Tahir Ali, Ayesha Ishtiaq, Iram Mushtaq, Neelum Ayaz, Muhammad Ishtiaq Jan, Wajiha Khan, Uzma Khan, Iram Murtaza

Abstract read
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In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tahir AliSignal Transduction Laboratory, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan. tali@bs.qau.edu.pk.
Ayesha IshtiaqSignal Transduction Laboratory, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Iram MushtaqSignal Transduction Laboratory, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Neelum AyazSignal Transduction Laboratory, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Muhammad Ishtiaq JanSignal Transduction Laboratory, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Wajiha KhanCOMSATS University Abbottabad Campus, Mansehra, KPK, Pakistan.
Uzma KhanHazara University, Mansehra, KPK, Pakistan.
Iram MurtazaSignal Transduction Laboratory, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan. irambch@qau.edu.pk.ORCID http://orcid.org/0000-0001-8092-5211
Quaid-i-Azam University · PKCOMSATS University Islamabad · PKHazara University · PK

Funding

quaid-i-azam university URF
6 · The paper itself

Abstract

Diabetic kidney disease is one of the most common microvascular complications of diabetes mellitus with consequences of diabetic nephropathy. Here we amined to evaluate the nephroprotective potential of methanolic Mentha longifolia (MML) against serotonin-induced hypoglycemia allied toxicity in the rat model of diabetes. Diabetes was induced in rats via alloxan administration and validated by blood glucose level measurement. After that, the animals were treated with serotonin and methanolic extract of Mentha longifolia. Surprisingly, serotonin treatment significantly reduced the glucose levels to hypoglycemic conditions, accompanied by impaired redox defense system, abnormal kidney histopathology, dyslipidemia, and altered level of liver toxicity markers. Interestingly these changes were rescued by the methanolic extract of M. longifolia. The present study suggests that impaired serotonin levels during diabetic conditions may accelerate hypoglycemic allied free radical-dependent abnormalities; however, medicinal plants like M. longifolia can reduce these deleterious effects by scavenging free radicals and their associated toxicity.

Indexed as

Diabetes MellitusHypoglycemiaMenthaAnimalsBlood GlucoseHypoglycemic AgentsPlant ExtractsRatsReactive Oxygen SpeciesSerotoninBlood GlucoseHypoglycemic AgentsPlant ExtractsReactive Oxygen SpeciesSerotoninDiabetic kidney diseasesMentha longifoliaReactive oxygen speciesSerotonin

Identifiers

PMID34716886
OpenAlexW3210426308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.