Evidence map›Paper›PMID 34716791›Full record

Trial reportEuropean journal of nutrition2022

Extra virgin olive oil high in polyphenols improves antioxidant status in adults: a double-blind, randomized, controlled, cross-over study (OLIVAUS).

Katerina Sarapis, Elena S George, Wolfgang Marx, Hannah L Mayr, Jane Willcox, Tammy Esmaili, Katie L Powell, Oladayo S Folasire, Anna E Lohning, Manohar Garg and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
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  18. Mediterranean Diet and Melatonin: A Systematic Review.Antioxidants (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Katerina SarapisDepartment of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-3397-8588
Elena S GeorgeDepartment of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-1385-2371
Wolfgang MarxDepartment of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-8556-8230
Hannah L MayrSchool of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0001-7356-653X
Jane WillcoxDepartment of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-6306-5333
Tammy EsmailiSchool of Life Sciences, La Trobe University, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0002-3014-9581
Katie L PowellFaculty of Health Sciences and Medicine, Bond University, Robina, QLD, 4229, Australia.
Oladayo S FolasireFaculty of Health Sciences and Medicine, Bond University, Robina, QLD, 4229, Australia.
Anna E LohningFaculty of Health Sciences and Medicine, Bond University, Robina, QLD, 4229, Australia.
Manohar GargNutraceuticals Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia.
Colleen J ThomasDepartment of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0003-0457-715X
Catherine ItsiopoulosSchool of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0003-1397-4149
George MoschonisDepartment of Dietetics, Nutrition and Sport, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Melbourne, VIC, 3086, Australia. g.moschonis@latrobe.edu.au.ORCID http://orcid.org/0000-0003-3009-6675
La Trobe University · AUBond University · AUDeakin University · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOlive oil polyphenols have been associated with cardiovascular health benefits. This study examined the antioxidant and anti-inflammatory effect of extra-virgin high polyphenol olive oil (HPOO) vs. low polyphenol olive oil (LPOO) in healthy Australian adults.

methodsIn a double-blind cross-over trial, 50 participants (aged 38.5 ± 13.9 years, 66% females) were randomized to consume 60 mL/day of HPOO (320 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for three weeks. Following a 2-week wash-out period, participants crossed-over to the alternate treatment. Plasma oxidized low-density lipoprotein (ox-LDL), total antioxidant capacity (TAC), high-sensitivity C-reactive protein (hs-CRP) and anthropometrics were measured at baseline and follow-up.

resultsFourty-three participants completed the study. Although there were no significant differences between treatments in the total sample, plasma ox-LDL decreased by 6.5 mU/mL (95%CI - 12.4 to - 0.5) and TAC increased by 0.03 mM (95% CI 0.006-0.05) only in the HPOO arm. Stratified analyses were also performed by cardiovascular disease risk status defined by abdominal obesity (WC > 94 cm in males, > 80 cm in females) or inflammation (hs-CRP > 1 mg/L). In the subgroup with abdominal obesity, ox-LDL decreased by 13.5 mU/mL (95% CI - 23.5 to - 3.6) and TAC increased by 0.04 mM (95% CI 0.006-0.07) only after HPOO consumption. In the subgroup with inflammation, hs-CRP decreased by 1.9 mg/L (95% CI - 3.7 to -0.1) only in the HPOO arm.

conclusionsAlthough there were no significant differences between treatments, the changes observed after HPOO consumption demonstrate the antioxidant and anti-inflammatory effect of this oil, which is more pronounced in adults with high cardiometabolic risk (Clinical Trial Registration: ACTRN12618000706279).

Indexed as

AntioxidantsPolyphenolsAdultAustraliaCross-Over StudiesFemaleHumansMaleMiddle AgedOlive OilPlant OilsYoung AdultAntioxidantsOlive OilPlant OilsPolyphenolsAntioxidantCardiovascular diseaseExtra virgin olive oilInflammationOlive oilPolyphenols

Identifiers

PMID34716791
OpenAlexW3210796704

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.