Evidence map›Paper›PMID 34716694›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8

Xuedan He, Shiqi Zhou, Breandan Quinn, Wei-Chiao Huang, Dushyant Jahagirdar, Michael Vega, Joaquin Ortega, Mark D Long, Fumito Ito, Scott I Abrams and 1 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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  6. Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Xuedan HeUniversity at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Shiqi ZhouUniversity at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Breandan QuinnUniversity at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Wei-Chiao HuangUniversity at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Dushyant JahagirdarDepartment of Anatomy and Cell Biology, McGill University Montreal, Quebec, H3A1Y2, Canada.
Michael VegaDivision of Research and Innovation Partnerships, Northern Illinois University, DeKalb, IL, 60115, USA.
Joaquin OrtegaDepartment of Anatomy and Cell Biology, McGill University Montreal, Quebec, H3A1Y2, Canada.
Mark D LongDepartment of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center (RPCCC), Buffalo, NY, 14263, USA.
Fumito ItoDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Scott I AbramsDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.
Jonathan F LovellUniversity at Buffalo, State University of New York, Buffalo, NY, 14260, USA.ORCID 0000-0002-9052-884X
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · USMcGill University · CANorthern Illinois University · US

Funding

In situ radioimmunotherapy to maximize the engagement of conventional type 1 dendritic cells against non-T cell-inflamed tumorsR01CA255240 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ITO, FUMITO · 2021 to 2025
$2.0M
A Cobalt Porphyrin Nanoliposome Adjuvant for MHC-I-Restricted Cancer Peptide VaccinesR01CA247771 · NCI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ABRAMS, SCOTT I., LOVELL, JONATHAN F · 2020 to 2024
$1.9M
Adoptive Cell Therapy with Rejuvenated Antigen-Specific T CellsK08CA197966 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ITO, FUMITO · 2015 to 2019
$875k
Canadian Foundation for InnovationMcGill UniversityNCI NIH HHS K08 CA197966NCI NIH HHS R01 CA247771NCI NIH HHS R01 CA255240NIH HHS K08CA197966NIH HHS R01CA247771Northern Illinois University's Molecular Analysis Core
6 · The paper itself

Abstract

Short peptides reflecting major histocompatibility complex (MHC) class I (MHC-I) epitopes frequently lack sufficient immunogenicity to induce robust antigen (Ag)-specific CD8

Indexed as

Peptide LibraryAnimalsCD8-Positive T-LymphocytesDisease Models, AnimalLeukemiaLymphocyte ActivationMiceMice, Inbred BALB CPeptide Librarycancerimmunogenliposomesposition-scanning peptide librariesvaccines

Identifiers

PMID34716694
PMCPMC8693074
OpenAlexW3209654421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.