ReviewNature reviews. Neurology2021
Autonomic manifestations of epilepsy: emerging pathways to sudden death?
Review in Nature reviews. Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- [Incidence of sudden death in epilepsy (SUDEP): update and limitations].Der Nervenarzt · 2024Pooled it
- Sudden unexpected death in epilepsy and ictal asystole in patients with autoimmune encephalitis: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Feasibility of cardiac-based seizure detection and prediction: A systematic review of non-invasive wearable sensor-based studies.Epilepsia open · 2024Pooled it
- Drug-resistant epilepsy and mortality-Why and when do neuromodulation and epilepsy surgery reduce overall mortality.Epilepsia · 2022Pooled it
- Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic-clonic seizures.Epilepsia open · 2025Trial
- Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring.Annals of clinical and translational neurology · 2026Article
- Autonomic Network Signatures of Interictal Cardiorespiratory Dysfunction in Patients With Temporal Lobe Epilepsy.Neurology · 2026Article
- Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias.Nature communications · 2026Article
- Dynamic alterations in cardiac autonomic regulation during recurrent generalized seizures.iScience · 2026Article
- A smart mattress for detecting and correcting the prone position: A feasibility study toward night-time SUDEP prevention.Epilepsia open · 2026Article
- Patient-independent hybrid generative-discriminative modeling for seizure detection in long-term scalp EEG.Scientific reports · 2026Article
- Epilepsy and incident cardiovascular disease: A prospective UK Biobank cohort study.BMC public health · 2026Article
- Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea.Epilepsia open · 2026Article
- HRV features as potential biomarkers for auxiliary diagnosis in epilepsy.Scientific reports · 2026Article
- Towards bioelectric signal-enabled human healthcare monitoring: state-of-the-art, design strategies, challenge, and future.npj biomedical innovations · 2026Review
- Etiology, Symptoms, and Treatment of Epilepsy: Advances and Perspectives.Brain sciences · 2026Article
- Cardiac endogenous transmitter system: molecular features, functions, and clinical implications.European heart journal · 2026Review
- Quantitative EEG and dysautonomia in patients with temporal lobe epilepsy.Acta epileptologica · 2026Article
- Heart rate variability in epilepsy and its association with disease duration: a retrospective case-control study.Frontiers in neurology · 2026Article
- Beyond the spike: Functional (dissociative) seizures as a key to holistic attitudes in seizure disorders.Epilepsia · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epileptic networks are intimately connected with the autonomic nervous system, as exemplified by a plethora of ictal (during a seizure) autonomic manifestations, including epigastric sensations, palpitations, goosebumps and syncope (fainting). Ictal autonomic changes might serve as diagnostic clues, provide targets for seizure detection and help us to understand the mechanisms that underlie sudden unexpected death in epilepsy (SUDEP). Autonomic alterations are generally more prominent in focal seizures originating from the temporal lobe, demonstrating the importance of limbic structures to the autonomic nervous system, and are particularly pronounced in focal-to-bilateral and generalized tonic-clonic seizures. The presence, type and severity of autonomic features are determined by the seizure onset zone, propagation pathways, lateralization and timing of the seizures, and the presence of interictal autonomic dysfunction. Evidence is mounting that not all autonomic manifestations are linked to SUDEP. In addition, experimental and clinical data emphasize the heterogeneity of SUDEP and its infrequent overlap with sudden cardiac death. Here, we review the spectrum and diagnostic value of the mostly benign and self-limiting autonomic manifestations of epilepsy. In particular, we focus on presentations that are likely to contribute to SUDEP and discuss how wearable devices might help to prevent SUDEP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.