SynthesisNature communications2021
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Erratum issuedOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
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Corrections and comments
- Erratum issued
Authors and funding
83 authors at 20 institutions in 10 countries.
Wei-Yu LinTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-9267-7988
Sarah E FordhamTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Eric HungateSection of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Nicola J SunterTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Claire ElstobTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0003-4252-493X
Yaobo XuTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Catherine ParkTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Anne QuanteHelmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Konstantin StrauchHelmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Christian GiegerLudwig-Maximilians-Universität München, Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Munich, Germany.ORCID http://orcid.org/0000-0001-6986-9554
Andrew SkolSection of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Thahira RahmanTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Lara Sucheston-CampbellCollege of Pharmacy, The Ohio State University, Columbus, OH, USA.
Junke WangCollege of Pharmacy, The Ohio State University, Columbus, OH, USA.
Theresa HahnDepartment of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.ORCID http://orcid.org/0000-0002-3835-8855
Alyssa I Clay-GilmourArnold School of Public Health, Department of Epidemiology & Biostatistics, University of South Carolina, Greenville, USA.
Gail L JonesDepartment of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
Helen J MarrDepartment of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
Graham H JacksonDepartment of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
Tobias MenneDepartment of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
Mathew CollinDepartment of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0001-6585-9586
Adam IveyDepartment of Medical and Molecular Genetics, King's College Medical School, London, UK.
Robert K HillsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Alan K BurnettPaul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-1734-5817
Nigel H RussellDepartment of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Jude FitzgibbonBarts Cancer Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-9069-1866
Richard A LarsonSection of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9168-3203
Michelle M Le BeauSection of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Wendy StockSection of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
Olaf HeidenreichTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Abrar AlharbiTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
David J AllsupCentre for Atherothrombosis and Metabolic Disease, Hull York Medical School, Hull, UK.ORCID http://orcid.org/0000-0001-6159-6109
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-5268-0242
Jean NordenTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Anne M DickinsonTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Elisabeth DouglasTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Clare LendremTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-9435-7398
Ann K DalyTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Louise PalmWest Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK.
Kim PiechockiWest Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK.
Sally JeffriesWest Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK.
Martin BornhäuserDepartment of Haematological Medicine, The Rayne Institute, King's College London, London, UK.
Christoph RölligMedizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
Heidi AltmannMedizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
Leo RuhnkeMedizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
Desiree KunadtMedizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
Lisa WagenführMedizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
Heather J CordellPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-1879-5572
Rebecca DarlayPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Mette K AndersenDepartment of Clinical Genetics, University Hospital Rigshospitalet, Copenhagen, Denmark.
Maria C FontanaInstitute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy.
Giovanni MartinelliIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Giovanni MarconiIRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.ORCID http://orcid.org/0000-0001-6309-0515
Miguel A SanzHematology Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain.ORCID http://orcid.org/0000-0003-1489-1177
José CerveraHematology Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Inés Gómez-SeguíHematology Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Thomas CluzeauHematology department, Cote d'Azur University, CHU of Nice, Nice, France.
Chimène MoreilhonHematology department, Cote d'Azur University, CHU of Nice, Nice, France.
Sophie RaynaudHematology department, Cote d'Azur University, CHU of Nice, Nice, France.
Heinz SillDivision of Hematology, Medical University of Graz, Graz, Austria.ORCID http://orcid.org/0000-0003-0993-4371
Maria Teresa VosoUniversità di Roma Tor Vergata, Dipartimento di Biomedicina e Prevenzione, Rome, Italy.ORCID http://orcid.org/0000-0002-6164-4761
Francesco Lo-CocoUniversità di Roma Tor Vergata, Dipartimento di Biomedicina e Prevenzione, Rome, Italy.
Hervé DombretHôpital Saint-Louis, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris, France.
Meyling CheokUniv. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.ORCID http://orcid.org/0000-0002-7820-8026
Claude PreudhommeUniv. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
Rosemary E GaleDepartment of Haematology, University College London Cancer Institute, London, UK.
David LinchDepartment of Haematology, University College London Cancer Institute, London, UK.
Julia Gaal-Wesinger1st Department of Internal Medicine, Semmewleis University, Budapest, Hungary.
Andras Masszi3rd Department of Internal Medicine, Semmewleis University, Budapest, Hungary.
Daniel NowakDepartment of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0001-7130-7921
Wolf-Karsten HofmannDepartment of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Amanda GilkesDepartment of Haematology, University of Cardiff, Cardiff, UK.
Kimmo PorkkaHelsinki University Hospital Comprehensive Cancer Center, Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland.
Jelena D Milosevic FeenstraDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Robert KralovicsDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
David GrimwadeDepartment of Medical and Molecular Genetics, King's College Medical School, London, UK.
Manja MeggendorferMLL Munich Leukemia Laboratory, Munich, Germany.
Torsten HaferlachMLL Munich Leukemia Laboratory, Munich, Germany.
Szilvia KrizsánHCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-1782-9275
Csaba BödörHCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.ORCID http://orcid.org/0000-0002-0729-692X
Friedrich StölzelMedizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany. friedrich.stoelzel@uniklinikum-dresden.de.ORCID http://orcid.org/0000-0003-0653-5332
Kenan OnelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kenan.onel@mssm.edu.ORCID http://orcid.org/0000-0002-2021-6250
James M AllanTranslational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. james.allan@newcastle.ac.uk.ORCID http://orcid.org/0000-0002-7580-5087
Newcastle University · GBUniversity Hospital Carl Gustav Carus · DENational Health Service · GBUniversity of Chicago · USSemmelweis University · HUBirmingham Women's Hospital · GBInstituto de Salud Carlos III · ESIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITHeidelberg University · DEHelmholtz Zentrum München · DEInserm · FRKing's College School · GBLondon Cancer · GBMedical University of Vienna · ATMunich Leukemia Laboratory (Germany) · DEThe Ohio State University · USUniversity of Rome Tor Vergata · ITBlood Cancer UK · GBCardiff University · GBDélégation Paris 7 · FR
Funding
Genetic susceptibility to unrelated donor stem cell transplant-related mortalityR01HL102278 · NHLBI · ROSWELL PARK CANCER INSTITUTE CORP · PI HAHN, THERESA E, SUCHESTON-CAMPBELL, LARA · 2010 to 2013
$5.0MGenetic susceptibility to acute lymphocytic and myeloid leukemiaR03CA188733 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HAHN, THERESA E, SUCHESTON-CAMPBELL, LARA · 2015 to 2016
$176kCancer Research UK 24375Cancer Research UK 25643Medical Research Council G0700052Medical Research Council MR/P002005/1Medical Research Council MR/T004231/1NCI NIH HHS R03 CA188733NHLBI NIH HHS R01 HL102278
Abstract
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10
Indexed as
Polymorphism, Single NucleotideAldehyde ReductaseCase-Control StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHLA AntigensHumansLeukemia, Myeloid, AcuteMiddle AgedReproducibility of ResultsWhite PeopleAKR1B1 protein, humanAldehyde ReductaseHLA Antigens
Identifiers
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