Evidence map›Paper›PMID 34716313›Full record

ArticleCell death & disease2021

CD8

Neda Feizi, Chiara Focaccetti, Ilenia Pacella, Gloria Tucci, Alessandra Rossi, Massimo Costanza, Rosetta Pedotti, John Sidney, Alessandro Sette, Claudia La Rocca and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. The neuropathobiology of multiple sclerosis.Nature reviews. Neuroscience · 2024
    Review
  4. Review
  5. Article
  6. Background and roles: myosin in autoimmune diseases.Frontiers in cell and developmental biology · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Neda FeiziDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Chiara FocaccettiDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy.ORCID 0000-0002-7334-3966
Ilenia PacellaDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Gloria TucciDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Alessandra RossiDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Massimo CostanzaMolecular Neuro-Oncology Unit, Department of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy.
Rosetta PedottiMolecular Neuro-Oncology Unit, Department of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy.
John SidneyCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.
Claudia La RoccaLaboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), 80131, Naples, Italy.
Claudio ProcacciniLaboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), 80131, Naples, Italy.
Giuseppe MatareseLaboratorio di Immunologia, Istituto per l'Endocrinologia e l'Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), 80131, Naples, Italy.ORCID 0000-0001-9429-0616
Vincenzo BarnabaDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy. vincenzo.barnaba@uniroma1.it.ORCID 0000-0001-7908-8049
Silvia PiconeseDepartment of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161, Rome, Italy. silvia.piconese@uniroma1.it.ORCID 0000-0002-9685-5227
Sapienza University of Rome · ITInstitute for Experimental Endocrinology and Oncology · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITLa Jolla Institute for Immunology · USFondazione Santa Lucia · ITIstituto Pasteur · ITSan Raffaele University of Rome · IT

Funding

Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) IG-19939Fondazione Italiana Sclerosi Multipla (Italian Multiple Sclerosis Foundation) 2015/R-single/04Fondazione Italiana Sclerosi Multipla (Italian Multiple Sclerosis Foundation) 2016/R/18Fondazione Italiana Sclerosi Multipla (Italian Multiple Sclerosis Foundation) 2018/S/5Fondazione Italiana Sclerosi Multipla (Italian Multiple Sclerosis Foundation) 2019/R-single/053Fondazione Italiana Sclerosi Multipla (Italian Multiple Sclerosis Foundation) cod. 2019/R-Single/065Ministero della Salute (Ministry of Health, Italy) GR-2016-02363749Ministero della Salute (Ministry of Health, Italy) GR-2018-12366154Ministero della Salute (Ministry of Health, Italy) GR-2019-12368551Ministero della Salute (Ministry of Health, Italy) RF-2019-12371111Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN, n. 2017 K55HLC 001
6 · The paper itself

Abstract

The autoimmune immunopathology occurring in multiple sclerosis (MS) is sustained by myelin-specific and -nonspecific CD8

Indexed as

AnimalsApoptosisCD8-Positive T-LymphocytesCentral Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalEpitopes, T-LymphocyteFemaleImmunizationLymphocyte ActivationMaleMiceMice, Inbred C57BLMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinOvalbuminPeptide FragmentsEpitopes, T-LymphocyteMyelin-Oligodendrocyte GlycoproteinOvalbuminovalbumin (256-264)Peptide Fragments

Identifiers

PMID34716313
PMCPMC8556378
OpenAlexW3208633765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.