ArticleNature communications2021
3D printed biomimetic cochleae and machine learning co-modelling provides clinical informatics for cochlear implant patients.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Three-dimensional printing and cochlear implantation: a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- 3D-Printed Electroanatomic Twins of Cadaveric Cochleae: A Platform for Cochlear Implant Testing.Laryngoscope investigative otolaryngology · 2026Article
- Computational Insights Into Smart Bioelectronics in Digital Health Care (2020-2024): Topic Modeling Study.JMIR medical informatics · 2026Review
- Development of a 3D-printable bioactive polycaprolactone-collagen peptides filament for biomedical applications.Scientific reports · 2025Article
- 3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Imaging-guided deep tissue in vivo sound printing.Science (New York, N.Y.) · 2025Article
- Use of Computational Intelligence in Customizing Drug Release from 3D-Printed Products: A Comprehensive Review.Pharmaceutics · 2025Review
- 3D printed microneedles: revamping transdermal drug delivery systems.Drug delivery and translational research · 2025Review
- Emerging Wearable Acoustic Sensing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Investigating the Effect of Blurring and Focusing Current in Cochlear Implant Users with the Panoramic ECAP Method.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Microengineered neuronal networks: enhancing brain-machine interfaces.Annals of medicine and surgery (2012) · 2024Review
- Biofabrication methods for reconstructing extracellular matrix mimetics.Bioactive materials · 2024Review
- Biofabrication and biomanufacturing in Ireland and the UK.Bio-design and manufacturing · 2024Review
- Advanced neuroprosthetic electrode design optimized by electromagnetic finite element simulation: innovations and applications.Frontiers in bioengineering and biotechnology · 2024Review
- Models of Cochlea Used in Cochlear Implant Research: A Review.Annals of biomedical engineering · 2023Review
- 3D Bioprinting in Otolaryngology: A Review.Advanced healthcare materials · 2023Review
- Additive manufacturing of sustainable biomaterials for biomedical applications.Asian journal of pharmaceutical sciences · 2023Review
- Establishment of coverage-mass equation to quantify the corrosion inhomogeneity and examination of medium effects on iron corrosion.Regenerative biomaterials · 2023Article
- Microcapillary cell extrusion deposition with picolitre dispensing resolution.Bio-design and manufacturing · 2023Article
- The intraoperative relationship between intracochlear electrical field and excitability of the auditory nerve.Heliyon · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Cochlear implants restore hearing in patients with severe to profound deafness by delivering electrical stimuli inside the cochlea. Understanding stimulus current spread, and how it correlates to patient-dependent factors, is hampered by the poor accessibility of the inner ear and by the lack of clinically-relevant in vitro, in vivo or in silico models. Here, we present 3D printing-neural network co-modelling for interpreting electric field imaging profiles of cochlear implant patients. With tuneable electro-anatomy, the 3D printed cochleae can replicate clinical scenarios of electric field imaging profiles at the off-stimuli positions. The co-modelling framework demonstrated autonomous and robust predictions of patient profiles or cochlear geometry, unfolded the electro-anatomical factors causing current spread, assisted on-demand printing for implant testing, and inferred patients' in vivo cochlear tissue resistivity (estimated mean = 6.6 kΩcm). We anticipate our framework will facilitate physical modelling and digital twin innovations for neuromodulation implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.