Evidence map›Paper›PMID 34716285›Full record

ArticleAging2021

CircFAM120B knockdown inhibits osteosarcoma tumorigenesis via the miR-1205/PTBP1 axis.

Jia-Ju Li, Ming-Yue Xiong, Tian-Yu Sun, Chang-Bin Ji, Run-Tao Guo, Ya-Wei Li, Hong-Yu Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Osteosarcoma in a ceRNET perspective.Journal of biomedical science · 2024
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jia-Ju LiDepartment of Traumatology, The First Affiliated Hospital, And College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China.
Ming-Yue XiongDepartment of Traumatology, The First Affiliated Hospital, And College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China.
Tian-Yu SunDepartment of Traumatology, The First Affiliated Hospital, And College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China.
Chang-Bin JiDepartment of Traumatology, The First Affiliated Hospital, And College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China.
Run-Tao GuoDepartment of Traumatology, The First Affiliated Hospital, And College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China.
Ya-Wei LiDepartment of Ophthalmology, XiPing County People's Hospital, Zhumadian 463900, Henan, China.
Hong-Yu GuoDepartment of Traumatology, The First Affiliated Hospital, And College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteosarcoma (OS) is a highly prevalent bone malignancy with poor clinical outcomes. Expression of the circular RNA, hsa_circ_0078767 (circFAM120B) is elevated in OS, however, its mechanisms in OS are unclear.

methodsCircFAM120B levels were detected in OS tissue and cell lines. Silenced circFAM120B experiments were performed to assess its effects on OS

resultsCircFAM120B and the transcription factor, PTBP1 were elevated in OS tissue and cell lines, while miR-1205 was poorly expressed. Silenced circFAM120B significantly suppressed

conclusionWe hypothesize circFAM120B functions as a miR-1205 sponge to elevate PTBP1 levels, enhancing OS progression and associated malignant phenotypes. Thus, circFAM120B may function as a crucial mediator during OS progression.

Indexed as

Bone NeoplasmsOsteosarcomaAnimalsBone and BonesCarcinogenesisCell Line, TumorGene Knockdown TechniquesHeterogeneous-Nuclear RibonucleoproteinsHumansMaleMiceMice, Inbred BALB CMicroRNAsPolypyrimidine Tract-Binding ProteinRNA, CircularHeterogeneous-Nuclear RibonucleoproteinsMicroRNAsMIRN1205 microRNA, humanPolypyrimidine Tract-Binding ProteinPTBP1 protein, humanRNA, CircularcircRNAos

Identifiers

PMID34716285
PMCPMC8580345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.