ArticleProceedings of the National Academy of Sciences of the United States of America2021
Mammalian face as an evolutionary novelty.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 37 citations in OpenAlex.
- Patterns of interspecific variation in labial microarchitecture among anthropoid primates and the evolution of the hominin lips.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Age-dependent development of the interincisive suture: a CT-based study on prevalence and dimensions.Anatomical science international · 2026Article
- Prenatal growth patterns of the upper jaw complex with implications for laryngeal echolocation in bats.Journal of anatomy · 2025Article
- On the Maxillofacial Development of Mice, Mus musculus.Journal of morphology · 2025Article
- Sexual Dimorphism of Foetal Sheep Skulls During the Second and Third Periods of Pregnancy.Veterinary medicine and science · 2025Article
- A Novel Approach to Study Cranial Shape in Children with Normal and Sagittal Synostosis: An Application of Geometric Morphometrics.Neurologia medico-chirurgica · 2025Article
- Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions.Communications biology · 2025Article
- Computational investigation of the social function of domestic cat facial signals.Scientific reports · 2024Article
- Developmental origin of the mammalian premaxilla.Developmental biology · 2023Article
- Derived faunivores are the forerunners of major synapsid radiations.Nature ecology & evolution · 2023Article
- Article
- Review
- Modularity, homology, heterochrony: Gavin de Beer's legacy to the mammalian skull.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Evolution, conservatism and overlooked homologies of the mammalian skull.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Evolutionary mechanisms modulating the mammalian skull development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Marsupials and Multi-Omics: Establishing New Comparative Models of Neural Crest Patterning and Craniofacial Development.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anterior end of the mammalian face is characteristically composed of a semimotile nose, not the upper jaw as in other tetrapods. Thus, the therian nose is covered ventrolaterally by the "premaxilla," and the osteocranium possesses only a single nasal aperture because of the absence of medial bony elements. This stands in contrast to those in other tetrapods in whom the premaxilla covers the rostral terminus of the snout, providing a key to understanding the evolution of the mammalian face. Here, we show that the premaxilla in therian mammals (placentals and marsupials) is not entirely homologous to those in other amniotes; the therian premaxilla is a composite of the septomaxilla and the palatine remnant of the premaxilla of nontherian amniotes (including monotremes). By comparing topographical relationships of craniofacial primordia and nerve supplies in various tetrapod embryos, we found that the therian premaxilla is predominantly of the maxillary prominence origin and associated with mandibular arch. The rostral-most part of the upper jaw in nonmammalian tetrapods corresponds to the motile nose in therian mammals. During development, experimental inhibition of primordial growth demonstrated that the entire mammalian upper jaw mostly originates from the maxillary prominence, unlike other amniotes. Consistently, cell lineage tracing in transgenic mice revealed a mammalian-specific rostral growth of the maxillary prominence. We conclude that the mammalian-specific face, the muzzle, is an evolutionary novelty obtained by overriding ancestral developmental constraints to establish a novel topographical framework in craniofacial mesenchyme.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.