ArticleProceedings of the National Academy of Sciences of the United States of America2021
Configurational fingerprints of multicellular living systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Modeling developmental morpho-dynamics at single-cell resolution.Nature methods · 2026Article
- MultiCell: geometric learning in multicellular development.Nature methods · 2026Article
- Zn-IMP 3D Coordination Polymers for Drug Delivery: Crystal Structure and Computational Studies.Polymers · 2025Article
- Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D.bioRxiv : the preprint server for biology · 2025Article
- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Epithelial Layer Fluidization by Curvature-Induced Unjamming.Physical review letters · 2025Article
- Polarity-JaM: an image analysis toolbox for cell polarity, junction and morphology quantification.Nature communications · 2025Article
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- Learning collective cell migratory dynamics from a static snapshot with graph neural networks.ArXiv · 2024Article
- Signatures of structural disorder in the developingPRX life · 2024Article
- The energetics of cellular life transitions.Life metabolism · 2024Article
- Topological packing statistics of living and nonliving matter.Science advances · 2023Article
- Biophysical informatics reveals distinctive phenotypic signatures and functional diversity of single-cell lineages.Bioinformatics (Oxford, England) · 2023Article
- Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine.Small (Weinheim an der Bergstrasse, Germany) · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cells cooperate as groups to achieve structure and function at the tissue level, during which specific material characteristics emerge. Analogous to phase transitions in classical physics, transformations in the material characteristics of multicellular assemblies are essential for a variety of vital processes including morphogenesis, wound healing, and cancer. In this work, we develop configurational fingerprints of particulate and multicellular assemblies and extract volumetric and shear order parameters based on this fingerprint to quantify the system disorder. Theoretically, these two parameters form a complete and unique pair of signatures for the structural disorder of a multicellular system. The evolution of these two order parameters offers a robust and experimentally accessible way to map the phase transitions in expanding cell monolayers and during embryogenesis and invasion of epithelial spheroids.
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Registered trials
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